Results 61 to 70 of about 339,294 (253)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Probing the antioxidant activity of functional proteins and bioactive peptides in Hermetia illucens larvae fed with food wastes

Scientific Reports, 2022
Food waste is becoming more prevalent, and managing it is one of the most important issues in terms of food safety. In this study, functional proteins and bioactive peptides produced from the enzymatic digestion of black soldier fly (Hermetia illucens L.,
Jiaxin Lu, Yuwen Guo, Atif Muhmood, Bei Zeng, Yizhan Qiu, Pan Wang, Lianhai Ren   +6 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Pseudouridine Synthase RsuA Captures an Assembly Intermediate That Is Stabilized by Ribosomal Protein S17

Biomolecules, 2020
The ribosome is a large ribonucleoprotein complex that synthesizes protein in all living organisms. Ribosome biogenesis is a complex process that requires synchronization of various cellular events, including ribosomal RNA (rRNA) transcription, ribosome ...
Kumudie Jayalath, Sean Frisbie, Minhchau To, Sanjaya Abeysirigunawardena   +3 more
doaj   +1 more source

RNA G-quadruplex structures control ribosomal protein production

Scientific Reports, 2021
Four-stranded G-quadruplex (G4) structures form from guanine-rich tracts, but the extent of their formation in cellular RNA and details of their role in RNA biology remain poorly defined.
Dhaval Varshney, Sergio Martinez Cuesta, Barbara Herdy, Ummi Binti Abdullah, David Tannahill, Shankar Balasubramanian   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Isolation and identification of Pseudoxanthomonas winnipegensis from blood culture by MALDI-MS

Frontiers in Cellular and Infection Microbiology
Pseudoxanthomonas is a genus primarily isolated from environmental samples and causes opportunistic infections. In this study, we conducted a detailed investigation of P.
Satomi Takei, Satomi Takei, Tatsuya Nagasawa, Yuji Sekiguchi, Junya Fujimura, Kanae Teramoto, Kanae Teramoto, Mitsuru Wakita, Teruo Kirikae, Teruo Kirikae, Yuki Uehara, Yuki Uehara, Tatsuya Tada, Tatsuya Tada, Tatsuya Tada, Yoko Tabe, Yoko Tabe   +16 more
doaj   +1 more source

Survey and multigene characterization of stolbur phytoplasmas on various plant species in Serbia

Phytopathologia Mediterranea, 2013
Stolbur phytoplasmas were detected in 116 out of more than 200 samples from nine plant species col- lected in 2009‒2010 in Serbia. Phytoplasmas were detected and identified by restriction fragment length polymor- phism (RFLP) analysis of polymerase chain
Jelena MITROVIĆ, Snežana PAVLOVIĆ, Bojan DUDUK   +2 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source