Results 111 to 120 of about 421,073 (317)

Functional substitution of mouse ribosomal protein L27' for yeast ribosomal protein L29 in yeast ribosomes. [PDF]

Proceedings of the National Academy of Sciences, 1989
A cDNA clone of mouse ribosomal protein L27' was shown previously to be 62% identical in amino acid residues to yeast ribosomal protein L29. The L27' cDNA was expressed in yeast to determine the ability of the mouse protein to substitute for yeast L29 in assembling a functional ribosome.
Pierre Belhumeur, Daniel Skup, Geraldine Fleming, Howard M. Fried   +3 more
openaire   +3 more sources

RNA:protein ratio of the unicellular organism as a characteristic of phosphorous and nitrogen stoichiometry and of the cellular requirement of ribosomes for protein synthesis [PDF]

, 2006
Background Mean phosphorous:nitrogen (P:N) ratios and relationships of P:N ratios with the growth rate of organisms indicate a surprising similarity among and within microbial species, plants, and insect herbivores.
A Mehra, A Wada, AS Spirin, BJ Paul, C Condon, C Waldron, C Waldron, Carl E Sams, CH Williams, DE Larson, Duncan J Greenwood, EV Koonin, EV Koonin, FA Alberghina, GW Niven, H Bremer, H Bremer, J Bernhardt, JA Klappenbach, JF Martin, JF Martin, JJ Elser, JJ Elser, JJ Elser, John T Ammons, JT Auten, KW Boehlke, L Kerkhof, M Ehrenberg, M Ehrenberg, MR Knecht, R Mikkola, R Nieder, R Schmid, RA Cox, RG Westendorp, RJ Geider, RJ Lawrence, RO Poyton, RW Mink, RW Shulman, RW Sterner, S Gusewell, S Jonasson, T Moss, T Nyström, Tatiana V Karpinets, TM Walker, WM El-Sharoud   +48 more
core   +4 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Ribosome self-assembly leads to overlapping reproduction cycles and increases growth rate [PDF]

arXiv, 2018
In permissive environments, E. coli can double its dry mass every 21 minutes. During this time, ribosomes, RNA polymerases, and the proteome are all doubled. Yet, the question of how to relate bacterial doubling time to other biologically relevant time scales in the growth process remains illusive, due to the complex temporal nesting pattern of these ...
arxiv  

Microtubule-dependent ribosome localization in C. elegans neurons. [PDF]

, 2017
Subcellular localization of ribosomes defines the location and capacity for protein synthesis. Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic investigations of the cell biology of ribosome dynamics. Here,
Ellisman, Mark H, Goncharov, Alexandr, Jin, Yishi, Noma, Kentaro   +3 more
core   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero, Christina Freeman, Ruchi Shah, Renkui Bai, Hong Cui, Marian Castro, Zachary Myers, Eric Choy, Derek Chan, Molly Easter, Sophia Y. Zhao, Madeline Babros, Ruchi Garg, Matthew Deardorff, Franklin Moser, Tyler Mark Pierson   +15 more
wiley   +1 more source

Long non-coding RNAs as a source of new peptides [PDF]

, 2014
Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames and which have been termed long non-coding RNAs (lncRNAs). Despite the existence of several well-characterized lncRNAs that play roles in the regulation of gene expression, the vast majority of them do not yet have a known ...
arxiv   +1 more source

Size, shape, and flexibility of RNA structures

, 2006
Determination of sizes and flexibilities of RNA molecules is important in understanding the nature of packing in folded structures and in elucidating interactions between RNA and DNA or proteins.
Cantor C. R., Changbong Hyeon, D. Thirumalai, Ruxandra I. Dima, Zuker M.   +4 more
core   +1 more source

Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing [PDF]

, 2002
Many analyses have examined subnucleolar structures in eukaryotic cells, but the relationship between morphological structures, pre-rRNA processing, and ribosomal particle assembly has remained unclear.
Gadal, O, Gas, N, Gleizes, P E, Hurt, E, Petfalski, E, Strauss, D, Tollervey, D   +6 more
core   +2 more sources