Results 111 to 120 of about 1,994,746 (285)

Saporins - Type 1 Ribosome-inactivating proteins from soapwort (saponaria officinalis L.) [PDF]

, 1995
Ribosome-inactivating proteins (RlPs) are found distributed throughout the plant kingdom. These proteins possess a RNA N-glycosidase activity whereby the depurination of a specific adenine residue from the large ribosomal subunit renders eukaryotic and ...
Sinclair, Lesley Jean
core  

Ribosomal proteins indentified in IE2-p86SG associated complex.

, 2013
Note: Representative ribosomal proteins used to draw protein interaction network are in bold and underlined.
Mark F. Stinski (244637), Guixin Du (498138)   +1 more
core   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

The Effects of Palmitoylethanolamide or Ibuprofen on the Abundance Profile and Synthesis Rate of Proteins in C2C12 Skeletal Myotubes

FASEB BioAdvances
Palmitoylethanolamide (PEA) and ibuprofen (IBU) exert anti‐inflammatory effects that may influence skeletal muscle adaptation; however, their impact on muscle proteome dynamics remains unclear.
Paige L. Cole, Connor A. Stead, Jatin G. Burniston, Daniel J. Owens   +3 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Alternative ribosomal protein RpmE2 is produced under zinc limitation in Neisseria gonorrhoeae and slows translation and bacterial growth

mBio
To enhance its pathogenic potential, Neisseria gonorrhoeae (Gc) pirates zinc from human metal sequestration proteins using TonB-dependent outer membrane transport systems.
Amy L. Forehand, Kinga Malezyna, Keena S. Thomas, Ian J. Glomski, Cynthia Nau Cornelissen, Ahmad Jomaa, Alison K. Criss   +6 more
doaj   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Analysis of proteins by a radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis

Frontiers in Molecular Biosciences
Kaltschmidt and Wittmann made significant advances in protein separation techniques by pioneering the two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) method. However, it possessed two serious weaknesses.
Akira Wada, Masami Ueta, Chieko Wada, Yasushi Maki, Takehito Tanzawa, Hideji Yoshida   +5 more
doaj   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

The multifaceted roles of ribosomal P complex in cancer

World Journal of Surgical Oncology
The ribosomal P complex, a flexible lateral stalk structure of the ribosomal large subunit, consists of the RPLP0, RPLP1, and RPLP2 proteins, and is essential for the elongation phase of protein biosynthesis.
Bokang Yan, Jiaxing Guo, Weiwei Lai, Yuanbing Chen, Zuli Wang, Yuanhao Peng, Shi Chang   +6 more
doaj   +1 more source