Results 251 to 260 of about 421,073 (317)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media

ChemBioChem, EarlyView.
Peptide synthesis either on solid support or in solution for the potential development of new peptide drugs is facing a new challenge consisting in the progressive elimination of toxic polar aprotic solvents in favor of the more environmentally friendly water.
Francesca Bordignon, Alessandro Scarso, Alessandro Angelini   +2 more
wiley   +1 more source

Discovery and In Vitro Reconstitution of Closoxazole Biosynthesis from Pyxidicoccus fallax

ChemBioChem, EarlyView.
The myxobacterium Pyxidicoccus fallax is found to be a producer of benzoxazole‐containing natural products named closoxazoles. In vitro studies with the biosynthetic enzymes reveal new insights into the reaction mechanism for closoxazole formation.
Lucia Lernoud, Rimonda Jakob, Lars Warnick, Marie Luisa Marx, Lea Winand   +4 more
wiley   +1 more source

Selective [9‐15N] Guanosine for Nuclear Magnetic Resonance Studies of Large Ribonucleic Acids

ChemBioChem, EarlyView.
The small chemical shift anisotropy of nitrogen‐15 at the 9‐position in guanine (15N9‐G) leads to long T2 values and narrow NMR lines, particularly attractive to probe structure and dynamics of large (>200 nucleotide) ribonucleic acids (RNAs). RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that ...
Solomon K. Attionu, Rita Dill, Michael F. Summers, David A. Case, Jan Marchant, Theodore K. Dayie   +5 more
wiley   +1 more source

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

ChemBioChem, Accepted Article.
Nucleophosmin 1(NPM1) is an abundant human protein endowed with many functions whose dysregulation leads to various cancers and mutations are relevant in Acute Myeloid Leukemia (AML). In the wild type form, pentameric NPM1 resides mainly in the nucleolus even if it shuttles toward the cytosol exerting its chaperon function, conversely in AML‐mutated ...
Daniele Florio, Sara La Manna, Giada Raffaella Fiore, Valentina Roviello, Giuliano Castellano, Sossio Fabio Graziano, Anna Maria Malfitano, Daniela Marasco   +7 more
wiley   +1 more source

An evolutionarily conserved phosphoserine-arginine salt bridge in the interface between ribosomal proteins uS4 and uS5 regulates translational accuracy in Saccharomyces cerevisiae. [PDF]

Nucleic Acids Res
Joshi K, Luisi B, Wunderlin G, Saleh S, Lilly A, Okusolubo T, Farabaugh PJ.   +6 more
europepmc   +1 more source

Biosynthesis of the Fungal Cyclic Lipodepsipeptide Pleosporacin, a New Selective Inhibitor of the Phytopathogen Botrytis cinerea

ChemBioChem, EarlyView.
Bioactivity‐guided isolation led to the discovery of a potent and selective inhibitor of the phytopathogen Botrytis cinerea, pleosporacin (1), from mycelia extracts of the fungal strain Pleosporales sp. IBWF 020‐21. The biosynthesis of the nonribosomal cyclic lipodepsipeptide 1 was elucidated via heterologous reconstitution in Aspergillus oryzae ...
Carsten Wieder, Rainer Wiechert, Alexander Yemelin, Louis Pergaud Sandjo, Eckhard Thines, Till Opatz, Anja Schüffler   +6 more
wiley   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

Cell cycle specific, differentially tagged ribosomal proteins to measure phase specific transcriptomes from asynchronously cycling cells. [PDF]

Sci Rep
Cochran JD, Leathers TA, Maldosevic E, Siejda KW, Vitello J, Lee H, Bradley LA, Young A, Jomaa A, Wolf MJ.   +9 more
europepmc   +1 more source