Results 241 to 250 of about 1,591,440 (405)

Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells

Advanced Science, EarlyView.
Nanoparticles are used to improve immunomodulatory therapies, but the impact of drug‐free nanomaterials on the immune system remains unknown. Screening common biomedical nanoparticles (NPs) reveals that PLGA NPs enhanced NK cell anti‐tumoral activity and transcriptional activation in human NK and pan T cells.
Vincent Mittelheisser, Olivier Lefebvre, Mainak Banerjee, Shayamita Ghosh, Amandine Dupas, Marie‐Charlotte Diringer, Juliette Blumberger, Louis Bochler, Sébastien Harlepp, Annabel Larnicol, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Chloé Moritz, Christine Carapito, Raphaël Carapito, Loïc J. Charbonnière, François Lux, Olivier Tillement, Jacky G. Goetz, Alexandre Detappe   +20 more
wiley   +1 more source

NMR characterisation of the antibiotic resistance-mediating 32mer RNA from the 23S ribosomal RNA. [PDF]

Biomol NMR Assign
Muhs C, Kemper L, Richter C, Lavore F, Weingarth M, Wacker A, Schwalbe H.   +6 more
europepmc   +1 more source

Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases.

Infectious Disease Clinics of North America, 2016
Y. Doi, J. Wachino, Y. Arakawa
semanticscholar   +1 more source

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

Chemical nucleases are a robust alternative for RNase H cleavage of human ribosomal RNA. [PDF]

PLoS One
Wesseling H, Krug D, Wehrheim M, Göbel MW, Kaiser S.   +4 more
europepmc   +1 more source

Complementary sequences 1700 nucleotides apart form a ribonuclease III cleavage site in Escherichia coli ribosomal precursor RNA.

, 1978
R A Young, Joan A. Steitz
openalex   +1 more source

Internal Phase Separation in Synthetic DNA Condensates

Advanced Science, EarlyView.
The modular, programmable system of DNA nanostructures developed provides programmatic control over multiphase condensate behavior, enabling mapping onto a predictive Flory‐Huggins model. This combined experimental and theoretical framework will help address open questions in condensate biophysics and facilitate the rational design of functional ...
Diana A. Tanase, Dino Osmanović, Roger Rubio‐Sánchez, Layla Malouf, Elisa Franco, Lorenzo Di Michele   +5 more
wiley   +1 more source

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet, Michael S. Hildebrand, James D. Mills, Gary P. Brennan, Tore Eid, Susan A. Masino, Vicky Whittemore, Laura Bindila, Kevin K. Wang, Manisha Patel, Piero Perucca, Christopher A. Reid   +11 more
wiley   +1 more source

Peptide Hormone‐Mediated Regulation of Plant Development and Environmental Adaptability

Advanced Science, EarlyView.
In this review, recent advances in understanding the roles of plant peptide hormones in regulating growth, reproduction, and environmental adaptability are systematically summarized. It further elucidates the challenges in studying these peptides, such as their low abundance, functional redundancy, and complex signaling mechanisms, and highlights their
Xin Li, Liping Zhu, Huiqin Wang, Xin Zhou, Manhong Wang, Libei Li, Feng Liu, Jie Sun, Guanghui Xiao   +8 more
wiley   +1 more source

Integration of Metabolomics and 16S Ribosomal RNA Sequencing to Elucidate the Pathogenesis of Ankylosing Spondylitis. [PDF]

Immun Inflamm Dis
Wang X, Xu H, Chao Y, Sun C, Wang T, Fan X, Tang L, Xu S, Xie C.   +8 more
europepmc   +1 more source