Results 321 to 330 of about 1,591,440 (405)

Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase. [PDF]

Proc Natl Acad Sci U S A
Toubdji S, Thullier Q, Kilz LM, Marchand V, Yuan Y, Sudol C, Goyenvalle C, Jean-Jean O, Rose S, Douthwaite S, Hardy L, Baharoglu Z, de Crécy-Lagard V, Helm M, Motorin Y, Hamdane D, Brégeon D.   +16 more
europepmc   +1 more source

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

Chemistry &Biodiversity, EarlyView.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +8 more
wiley   +1 more source

Comparative analysis of bacterial abundance and diversity in tumour tissue of oral squamous cell carcinoma and non-tumour tissue: insights from a systematic review of 16S ribosomal RNA sequencing. [PDF]

BMC Oral Health
Mohapatra S, Panda S, Mohanty N, Mishra BP.   +3 more
europepmc   +1 more source

Poly(ethylene Glycol)‐Based Peptidomimetics (Pegtides) of Antimicrobial Peptides

ChemBioChem, EarlyView.
Polyethylene glycol (PEG) is commonly used to improve the pharmacokinetics and pharmacodynamics of therapeutic candidates by conjugation. Here PEG is exploited for peptidomimetic conversion of antimicrobial peptides (AMPs), as candidate antibacterial agents, by replacing their polyamide backbone. The pegtides obtained thereby can be readily synthesized
Conor Shine, John R. F. B. Connolly, Robert D. Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P. Buijs, Hawraa Shahrour, Nathaniel I. Martin, Eoghan O'Neill, George Amarandei, Jimmy Muldoon, Marc Maresca, Deirdre Fitzgerald‐Hughes, Marc Devocelle   +13 more
wiley   +1 more source

A role for a Trypanosoma brucei cytosine RNA methyltransferase homolog in ribosomal RNA processing. [PDF]

PLoS One
Militello KT, Leigh J, Pusateri M, Read LK, Vogler D.   +4 more
europepmc   +1 more source

Diastereoselective, Diversifiable Synthesis and Biological Evaluation of the Virginiamycin Inducers, the Virginiae Butanolides

ChemBioChem, EarlyView.
Production of natural products is tightly regulated, resulting in many silent biosynthetic gene clusters. BarA is a repressor that downregulates production of the virginiamycin antibiotics. The VBs are ligands for BarA that reverse its repression of virginiamycin production.
Kylie G. Castator, Manuela Frias‐Gomez, Lauren E. Wilbanks, Elizabeth I. Parkinson   +3 more
wiley   +1 more source

Exploring the Substrate Flexibility of GrsB Thioesterase Leads to the Structural Reassignment of a Gramicidin S Variant

ChemBioChem, Accepted Article.
Gramicidin S (GS) is a cyclic decapeptide derived from two pentapeptides. The C‐terminal thioesterase (TE) domain of gramicidin S synthetase B (GrsB) dimerizes precursor pentapeptides and cyclizes the resulting linear decapeptide. Recently, a GS variant (GS‐SA), in which a single D‐Phe was replaced by L‐Ser(Allyl), was reported via precursor‐directed ...
Sho Konno, Tomoe Mizuguchi, Atsuko Suzuki, Miyu Tanaka, Fumihiro Ishikawa, Akihiro Taguchi, Atsuhiko Taniguchi, Genzoh Tanabe, Yoshio Hayashi   +8 more
wiley   +1 more source

Efficient Ribosomal Rna Depletion fromDrosophilaTotal Rna for Next-Generation Sequencing Applications

Koppaka O, Tandon S, Chodankar A, Pandit A, Bakthavachalu B.   +4 more
europepmc   +1 more source

Ribosomal RNA modification enzymes stimulate large ribosome subunit assembly in E. coli. [PDF]

Nucleic Acids Res
Ero R, Leppik M, Reier K, Liiv A, Remme J.   +4 more
europepmc   +1 more source