Ribosome-inactivating proteins [PDF]
Virulence, 2013 Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis.
Dodd, J.E. +2 more
core +6 more sources
Primary Sequence and Three-Dimensional Structural Comparison between Malanin and Ricin, a Type II Ribosome-Inactivating Protein [PDF]
ToxinsMalanin is a new type II ribosome-inactivating protein (RIP) purified from Malania oleifera, a rare, endangered tree is only found in the southwest of Guangxi Province and the southeast of Yunnan Province, China.
Yan Yuan, Shuxiao Wu, Philip J. R. Day
doaj +2 more sources
Revising the taxonomic distribution, origin and evolution of ribosome inactivating protein genes. [PDF]
PLoS ONE, 2013 Ribosome inactivating proteins are enzymes that depurinate a specific adenine residue in the alpha-sarcin-ricin loop of the large ribosomal RNA, being ricin and Shiga toxins the most renowned examples.
Walter J Lapadula +2 more
doaj +2 more sources
Structure of Ribosome-Inactivating Protein from Mirabilis jalapa and Its L12-Stalk-Dependent Inhibition of Escherichia coli Ribosome [PDF]
ToxinsMirabilis antiviral protein (MAP) is the type I ribosome-inactivating protein (RIP), which consists of an RNA N-glycosylase domain with no carbohydrate-binding domain.
Nanami Nishida +7 more
doaj +2 more sources
Anti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmin 1 [PDF]
Toxins, 2016 Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature.
Begoña Barriuso +7 more
doaj +2 more sources
Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina. [PDF]
PLoS ONE, 2013 Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined by ...
Inderdeep Kaur +5 more
doaj +2 more sources
Biophysical and Biochemical Assays for Screening Small Molecule Inhibitors Targeting Toxin–Ribosome Interactions [PDF]
ToxinsRibosome-inactivating proteins are a class of toxins that target eukaryotic ribosomes, inhibit protein synthesis, and ultimately induce cell death. Several of these toxins pose significant clinical and public health threats.
Eric J. Bryan +6 more
doaj +2 more sources
Molecularly imprinted polymers for protome analysis [PDF]
, 2008 Fast and efficient methods for the detection of insurgence and progression of diseases are at the basis of modern diagnostics and medicine. In this concern, biomarkers represent a powerful diagnostic tool, as their expression profiles well correlate ...
Bonini, Francesca
core +7 more sources
Antiviral Activity of Ribosome-Inactivating Proteins [PDF]
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the ...
Citores González, Lucía +2 more
openaire +4 more sources
Biochemical and genetic analyses of Jatropha curcas L. seed composition [PDF]
, 2011 Diminishing worldwide fossil fuel reserves coupled with the negative impact of their use on the environment has led to increased research and development of renewable energy sources.
He, Wei
core +6 more sources