Results 31 to 40 of about 3,389,293 (247)
Microbial Cell, 2015 Apoptosis is an active form of programmed cell death (PCD) that plays critical roles in the development, differentiation and resistance to pathogens in multicellular organisms. Ribosome inactivating proteins (RIPs) are able to induce apoptotic cell death
Birsen Çakır, Nilgun E. Tumer
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Eutirucallin, a RIP-2 type lectin from the latex of Euphorbia tirucalli L. presents proinflammatory properties. [PDF]
PLoS ONE, 2014 Lectins are carbohydrate-binding proteins that recognize and modulate physiological activities and have been used as a toll for detection and identification of biomolecules, and therapy of diseases.
Sanzio Silva Santana +6 more
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Ribosome‐inactivating proteins up to date
FEBS Letters, 1986 Ribosome‐inactivating proteins (RIPs) from plants inactivate eukaryotic ribosomes, as far as studied by rendering their 60 S subunit unable to bind elongation factor 2. These proteins seem widely distributed and possibly ubiquitous in plants. They are either type 1, those consisting of a single polypeptide chain, or type 2 (ricin and related toxins ...
Stirpe, Fiorenzo, Barbieri, Luigi
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Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins
Toxins, 2018 Ribosome-inactivating proteins (RIPs) are potent toxins that inactivate ribosomes by catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large rRNA.
Yijun Zhou +3 more
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A ribosome-inactivating protein in a Drosophila defensive symbiont. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance Symbioses between animals and microbes are now recognized as critical to many aspects of host health. This is especially true in insects, which are associated with diverse maternally transmitted endosymbionts that can protect against parasites and pathogens.
Hamilton PT +3 more
europepmc +4 more sources
Molecules, 2016 Antibody drug conjugates (ADC), comprised of highly potent small molecule payloads chemically conjugated to a full-length antibody, represent a growing class of therapeutic agents.
Shilpa Chooniedass +6 more
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2A-induced ribosome stalling [PDF]
, 2014 Originally 2A was characterised in foot-and-mouth disease virus. Site directed mutagenesis identified a C-terminus consensus motif [D(V/I)ExNPGP] and it is proposed that 2A interacts with the exit tunnel of the ribosome in a way that a specific peptide ...
Odon, Valèrie
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Evolution of Plant Ribosome-Inactivating Proteins [PDF]
, 2010 This contribution presents an updated analysis of the evolution of ribosome-inactivating proteins (RIPs) in plants. All evidence suggests that an ancestor of modern seed plants developed the RIP domain at least 300 million years ago. This ancestral RIP domain gave rise to a direct lineage of type 1 RIPs (i.e. primary type 1 RIPs) still present today in
Peumans, Willy J, Van Damme, Els
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Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin
Frontiers in Molecular Biosciences, 2023 Although the anti-cancer activity of ricin is well-known, its non-specific targeting challenges the development of ricin-derived medicines. In the present study, novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered
Yasser Ahmadi Moghaddam +3 more
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Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
Toxins, 2015 All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-
Manuel Garrosa +7 more
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