Results 51 to 60 of about 25,832 (246)

Novel Ribosome-inactivating Protein (RIP) Isolated from Trichosanthes dioica Induces Apoptosis in HeLa Cell Line

International Journal of Bio-Resource and Stress Management, 2021
Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate eukaryotic and prokaryotic rRNAs and thus interrupt protein synthesis during translation.
T. Ghosh, Y. Vashi, K. Barman, L. I. Singha   +3 more
doaj  

Improvement of the Pharmacological Properties of Maize RIP by Cysteine-Specific PEGylation

Toxins, 2016
To improve the pharmacological properties of maize ribosome-inactivating protein (maize RIP) for targeting HIV-infected cells, the previously engineered TAT-fused active form of maize RIP (MOD) was further engineered for cysteine-directed PEGylation.
Ka-Yee Au, Wei-Wei Shi, Shuai Qian, Zhong Zuo, Pang-Chui Shaw   +4 more
doaj   +1 more source

Involvement of loops 2 and 3 of alpha-sarcin on its ribotoxic activity [PDF]

, 2015
Ribotoxins are a family of fungal ribosome-inactivating proteins displaying highly specific ribonucleolytic activity against the sarcin/ricin loop (SRL) of the larger rRNA, with a-sarcin as its best-characterized member.
Castaño Rodríguez, Carlos, García Ortega, Lucía, Gavilanes, José G., Lacadena García-Gallo, Javier, Martínez del Pozo, Álvaro, Olombrada Sacristán, Miriam, Oñaderra Sánchez, Mercedes, Partida Hanon, Angélica   +7 more
core   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

Lectin domains at the frontiers of plant defense [PDF]

, 2014
Plants are under constant attack from pathogens and herbivorous insects. To protect and defend themselves, plants evolved a multi-layered surveillance system, known as the innate immune system.
Lannoo, Nausicaä, Van Damme, Els
core   +2 more sources

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Ribosome inactivation by Escherichia coli GTPase RsgA inhibits T4 phage

Frontiers in Microbiology, 2023
IntroductionBacteria must combat phages, and myriad bacterial anti-phage systems have been discovered that reduce host metabolism, for example, by depleting energetic compounds like ATP and NAD+. Hence, these systems indirectly inhibit protein production.
Laura Fernández-García, Laura Fernández-García, María Tomás, Thomas K. Wood   +3 more
doaj   +1 more source

Inducible antiviral activity and rapid production of the Ribosome-Inactivating Protein I from Phytolacca heterotepala in tobacco

, 2008
We studied the in vitro and in planta antiviral activity of the PhRIP I, a type 1 Ribosome-Inactivating Protein originally purified from leaves of the Phytolacca heterotepala.
ANTIMO DI MARO, AUGUSTO PARENTE, DANIELA ALIOTO, GIANDOMENICO CORRADO, LETIZIA POLITO, MARIAROSARIA SCARPETTA, R. RAO   +6 more
core   +1 more source

Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue

Advanced Science, EarlyView.
TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao, Zhan Shi, Peng Hu, Changping Wang, Hui Wang   +4 more
wiley   +1 more source

Antifungal Activity of Ribosome-Inactivating Proteins

Toxins
The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly. Plants are an excellent source for this purpose because they have developed defense mechanisms to cope with fungal infections.
Iglesias Álvarez, María del Rosario, Citores González, Lucía, Gay, Claudia C., Ferreras Rodríguez, José Miguel   +3 more
openaire   +3 more sources