Results 71 to 80 of about 3,389,293 (247)

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Interaction between maize ribosome-inactivating protein and ribosomes [PDF]

, 2011
Ribosome‐inactivating proteins (RIPs) represent a group of N‐glycosidases which can cleave the N‐glycosidic bond of adenine at 23S and 28S ribosomal RNA (rRNA) of ribosome and subsequently lead to a halt of protein synthesis and cell death.
Mak, ANS, Wong, KB, Shaw, PC, Au, SWM, Sze, KH, Ng, YM, Wu, WH   +6 more
core  

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA [PDF]

, 2010
The Nep1 (Emg1) SPOUT-class methyltransferase is an essential ribosome assembly factor and the human Bowen–Conradi syndrome (BCS) is caused by a specific Nep1D86G mutation. We recently showed in vitro that Methanocaldococcus jannaschii Nep1 is a sequence-
Valeska Schilling, Jan Philip Wurm, Britta Meyer, Michael Karas, Kötter, Peter, Bahr, Ute, Schilling, Valeska, Buchhaupt, Markus, Wöhnert, Jens, Ute Bahr, Karl-Dieter Entian, Matthias S. Leisegang, Karas, Michael (Prof. Dr.), Martin Held, Heckel, Alexander, Leisegang, Matthias S., Peter Kötter, Markus T. Bohnsack, Entian, Karl-Dieter, Markus Buchhaupt, Bohnsack, Markus, Held, Martin, Alexander Heckel, Meyer, Britta, Leisegang, Matthias, Jens Wöhnert, Karas, Michael, Wurm, Jan Philip   +27 more
core   +1 more source

Ribosome-Inactivating Proteins from Plants: A Historical Overview [PDF]

Molecules, 2016
This review provides a historical overview of the research on plant ribosome-inactivating proteins (RIPs), starting from the first studies at the end of eighteenth century involving the purification of abrin and ricin, as well as the immunological experiments of Paul Erlich. Interest in these plant toxins was revived in 1970 by the observation of their
BOLOGNESI, ANDREA, BORTOLOTTI, MASSIMO, MAIELLO, STEFANIA, BATTELLI, MARIA GIULIA, POLITO, LETIZIA   +4 more
openaire   +3 more sources

Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research

Molecules, 2017
The enzymes called ribosome‐inactivating proteins (RIPs) that are able to depurinate  nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline  research field, mostly because of their promising medical ...
Andrea Bolognesi, Massimo Bortolotti, Maria Giulia Battelli, Letizia Polito   +3 more
doaj   +1 more source

Production of Recombinant Gelonin Using an Automated Liquid Chromatography System

Toxins, 2020
Advances in recombinant DNA technology have opened up new possibilities of exploiting toxic proteins for therapeutic purposes. Bringing forth these protein toxins from the bench to the bedside strongly depends on the availability of production methods ...
Maria E. B. Berstad, Lawrence H. Cheung, Anette Weyergang   +2 more
doaj   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity [PDF]

Molecules, 2015
Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ...
Tejero Del Rio, Jesús, Jiménez López, María del Pilar, Quinto Fernández, Emiliano José, Córdoba Diaz, Damián, Garrosa García, Manuel, Córdoba Diaz, Manuel, Gayoso Rodríguez, Manuel José, Girbés Juan, Tomás   +7 more
openaire   +4 more sources

A systemic antiviral resistance-inducing protein isolated from Clerodendrum inerme Gaertn. is a polynucleotide:adenosine glycosidase (ribosome-inactivating protein) [PDF]

, 1996
Two systemic antiviral resistance-inducing proteins, CIP-29 and CIP-34, isolated from Clerodendrum inerme Gaertn. leaves, were tested for ribosome-inactivating properties.
Ghosal-Chowdhury P., Olivieri F., Valbonesi P., Srivastava S., Barbieri L., Prasad V., Bolognesi A., Stirpe F.   +7 more
core   +2 more sources