Results 91 to 100 of about 25,832 (246)

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

TM9SF2 Maintains Golgi Integrity and Regulates Ricin-Induced Cytotoxicity

Toxins
TM9SF2 belongs to a family of highly conserved nonaspanin proteins, and has been frequently identified as one of the important host factors for a plethora of lethal pathogens and toxins in previous genome-wide screening studies.
Yue Meng, Hongzhi Wan, Xinyu Wang, Lina Zhang, Ruozheng Xin, Lingyu Li, Yuhui Wang, Chengwang Xu, Hui Peng, Lu Sun, Bo Wang, Xiaotao Duan   +11 more
doaj   +1 more source

An N-Terminal Fragment of Yeast Ribosomal Protein L3 Inhibits the Cytotoxicity of Pokeweed Antiviral Protein in Saccharomyces cerevisiae

Toxins, 2014
We have previously shown that ribosomal protein L3 is required for pokeweed antiviral protein (PAP), a type I ribosome inactivating protein, to bind to ribosomes and depurinate the α-sarcin/ricin loop (SRL) in yeast.
Rong Di, Nilgun E. Tumer
doaj   +1 more source

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme. [PDF]

, 2016
Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome ...
Fujimori, Danica Galonić, Noda-Garcia, Lianet, Stojković, Vanja, Tawfik, Dan S   +3 more
core  

Comparative study of lectin domains in model species : new insights into evolutionary dynamics [PDF]

, 2017
Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses
Dang, Liuyi, De Schutter, Kristof, Eggermont, Lore, Tsaneva, Mariya Tsankova, Van Damme, Els, Van Holle, Sofie   +5 more
core   +3 more sources

Ribosome-Inactivating Proteins from Plants: A Historical Overview [PDF]

Molecules, 2016
This review provides a historical overview of the research on plant ribosome-inactivating proteins (RIPs), starting from the first studies at the end of eighteenth century involving the purification of abrin and ricin, as well as the immunological experiments of Paul Erlich. Interest in these plant toxins was revived in 1970 by the observation of their
BOLOGNESI, ANDREA, BORTOLOTTI, MASSIMO, MAIELLO, STEFANIA, BATTELLI, MARIA GIULIA, POLITO, LETIZIA   +4 more
openaire   +3 more sources

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

Advanced Science, EarlyView.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang, Chong Wang, Mengqi Han, Yi Yang, Teng Ma, Luoran Shang   +5 more
wiley   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Subcloning and Expression of ML1-stxB Fusion Gene of Mistletoe Lectin in E. coli and Production of its Antibody in Mouse

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Extract of mistletoe lectin (Viscum album L) leaves contains MLI protein that is a type 2 ribosome-inactivating protein (RIP2) with lectin properties.
Soheila Rahnamaei Yahyaabadi., Hossein Honari, Masoud Abdollahi, Seyed Mojtaba Aghaie, Mohamadali Ebrahimi   +4 more
doaj  

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source