Results 131 to 140 of about 24,109 (233)
The Role of N6‐Methyladenosine Modification in Health and Disease
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li +6 more
wiley +1 more source
The role of the nucleus in the control of mitochondrial precursor proteins in yeast
Abstract Mitochondria are essential organelles of eukaryotic cells, with vital roles in energy production, biosynthesis of macromolecules, and intracellular signaling. Their function depends on a complex proteome with proteins targeted to different mitochondrial sub‐compartments.
Kira Ritzenhofen +3 more
wiley +1 more source
Crystallization and preliminary X-ray studies of snake gourd lectin: homology with type II ribosome-inactivating proteins [PDF]
Arulanandam, Jeyaprakash +6 more
core +1 more source
Cytokinin–phyB signaling modulates PSII photochemistry during prolonged darkness. Summary Cytokinins (CKs) delay dark‐induced senescence, but how they tune photosynthetic function in darkness remains unclear. We investigated the effects of classical aromatic CK benzylaminopurine and CK‐derived compound 1‐(2‐methoxyethyl)‐3‐(1,2,3‐thiadiazol‐5‐yl)urea ...
Veronika Kábrtová +14 more
wiley +1 more source
Plant Peptides on the Rise: From Historical Insight to Future Applications
ABSTRACT Plant peptides constitute a rapidly expanding class of signalling molecules essential to plant physiology, mediating key processes such as development, stress adaptation, and immune responses. This review traces the history of plant peptide research, from the seminal discovery of systemin to the recent identification of non‐canonical peptides (
Shunxi Wang +5 more
wiley +1 more source
Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin‐Like Lasso Peptide
Biosynthesis of the class V lasso peptide gelatinamin A was elucidated by heterologous expression of the gel biosynthetic gene cluster in Bacillus subtilis. Its 3D structure was determined by NMR, and tailoring enzymes GelT and GelP were fully reconstituted in vitro.
Tiziana Svenningsen +9 more
wiley +1 more source
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu +6 more
wiley +1 more source
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu +13 more
wiley +1 more source
Estimation of Enzymatic Activities of Different Species of Mushrooms [PDF]
Mushrooms are widely spread saprophytic macro-organisms, belong to class fungi growing on dead organic matter of vegetative origin. They can utilize almost all agricultural wastes as their substrates for their growth and metabolism.
Chandra Mishra , Rahul
core
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source

