Results 201 to 210 of about 24,109 (233)

On the Distribution of Ribosome-Inactivating Proteins amongst Plants

Journal of Natural Products, 1985
The extracts from various parts (mostly seeds) of 56 different plants were examined for inhibition of protein synthesis by a rabbit reticulocyte lysate. Most extracts inhibited protein synthesis with an ID50 (concentration giving 50% inhibition) of 100 micrograms extract protein per ml, or less.
A, Gasperi-Campani, L, Barbieri, M G, Battelli, F, Stirpe   +3 more
openaire   +2 more sources

Ribosome Inactivating Proteins from an evolutionary perspective

Toxicon, 2017
Ribosome Inactivating Proteins (RIPs) are rRNA N-glycosidases that inhibit protein synthesis through the elimination of a single adenine residue from 28S rRNA. Many of these toxins have been characterized in depth from a biochemical and molecular point of view.
Walter Jesús, Lapadula, Maximiliano Juri, Ayub   +1 more
openaire   +2 more sources

Recent Progress in Research on Ribosome Inactivating Proteins

Current Protein and Peptide Science, 2009
The intent of this article is to review recent literature on ribosome inactivating proteins (RIPs) including isolation and characterization of new RIPs, studies on the crystal structures and mechanisms of actions of RIPs, the use of saporin-based neurotoxins to selectively lesion cholinergic neurons in neuroscience research, and the use of RIP-based ...
T B, Ng, Jack Ho, Wong, Hexiang, Wang
openaire   +2 more sources

Ribosome-inactivating proteins: From toxins to useful proteins

Toxicon, 2013
Ribosome-inactivating proteins (RIPs) either single-chain (type 1) or two-chain (type 2) are frequent in plants, often in multiple forms. They are RNA N-glycosidases, have antiviral, antifungal and insecticidal activity. Their expression in plants is increased under stressful conditions.
exaly   +3 more sources

Antiviral Activity Of Ribosome Inactivating Proteins In Medicine

Mini-Reviews in Medicinal Chemistry, 2004
Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs.
Bijal A, Parikh, Nilgun E, Tumer
openaire   +2 more sources

Ribosome Inactivating Proteins and Apoptosis

2010
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases which potently inhibit translation by inactivating ribosomes. RIPs have also been shown to possess the ability to induce apoptosis. A number of RIPs from different sources have been used to study the mechanism of apoptosis induction.
Deepa Sikriwal, Janendra K. Batra
openaire   +1 more source

Ribosome-inactivating proteins in edible plants and purification and characterization of a new ribosome-inactivating protein from Cucurbita moschata

Biochimica et Biophysica Acta (BBA) - General Subjects, 2006
The basic protein fraction of tissue extracts from 40 edible plants inhibited cell-free protein synthesis and released adenine from herring sperm DNA, thus having adenine glycosylase activity. This suggested the presence of ribosome-inactivating proteins (RIPs) in the plant extracts.
BARBIERI, LUIGI, POLITO, LETIZIA, BOLOGNESI, ANDREA, CIANI, MARIALIBERA, PELOSI, EMANUELE, FARINI, VALENTINA, Jha A. K., Sharma N., Vivanco J. M., Chambery A., Parente A., STIRPE, FIORENZO   +11 more
openaire   +6 more sources

Ribosome-Inactivating Proteins in Cereals

2010
Plants constitutively accumulate proteins that are either toxic or inhibitory against pathogens, including ribosome-inactivating proteins (RIPs) and N-glycosidases that depurinate the universally conserved α-sarcin loop of large rRNAs. Cereal RIPs share a high similarity with all the other RIPs; however, they retain characteristic features forming a ...
Carlotta Balconi, Chiara Lanzanova, Mario Motto   +2 more
openaire   +1 more source

The structure and function of ribosome-inactivating proteins

Trends in Plant Science, 1996
Many plants produce ribosome-inactivating proteins (RIPs) — enzymes that act on ribosomes in a highly specific way, thereby inhibiting protein synthesis. Some RIPs can bind to and enter cells, making them among the most toxic substances known. More commonly, however, RIPs are unable to enter healthy cells, and are therefore poorly cytotoxic. Their role
Martin R. Hartley, John A. Chaddock, Maureen S. Bonness   +2 more
openaire   +1 more source

Virus resistance mediated by ribosome inactivating proteins

2000
Publisher Summary This chapter describes recent advances in understanding the structure and function of ribosome inactivating proteins (RIPs) and the mechanism of their antiviral activity. RIPs are widely distributed among plants, fungi, and bacteria.
P, Wang, N E, Tumer
openaire   +2 more sources