Results 121 to 130 of about 358,575 (311)
Life, 2019 The early metabolism arising in a Thioester world gave rise to amino acids and their simple peptides. The catalytic activity of these early simple peptides became instrumental in the transition from Thioester World to a Phosphate World.
Hyman Hartman, Temple F. Smith
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Mechanism of ribosome stalling during translation of a poly(A) tail
Nature Structural & Molecular Biology, 2019 Faulty or damaged messenger RNAs are detected by the cell when translating ribosomes stall during elongation and trigger pathways of mRNA decay, nascent protein degradation and ribosome recycling.
V. Chandrasekaran +7 more
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Human Genomics, 2010 Understanding protein synthesis in bacteria and humans is important for understanding the origin of many human diseases and devising treatments for them.
Agirrezabala Xabier, Frank Joachim
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Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae
Toxins, 2010 The trichothecene mycotoxin deoxynivalenol (DON) is commonly encountered in human cereal foods throughout the world as a result of infestation of grains in the field and in storage by the fungus Fusarium.
James J. Pestka
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eLife, 2020 Ribosomal profiling has shed new light on how ribosomes can ignore stop codons in messenger RNA.
Kim M Keeling, David M Bedwell
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Translation with frameshifting of ribosome along mRNA transcript [PDF]
arXiv, 2015 Translation is an important process for prokaryotic and eukaryotic cells to produce necessary proteins for cell growth. Numerious experiments have been performed to explore the translational properties. Diverse models have also been developed to determine the biochemical mechanism of translation. However, to simplify the majority of the existing models,
arxiv
Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated. [PDF]
, 1988 We have previously shown that fully synthesized prepro-alpha-factor (pp alpha F), the precursor for the yeast pheromone alpha-factor, can be translocated posttranslationally across yeast rough microsomal (RM) membranes from a soluble, ribosome-free pool.
Garcia, PD, Walter, P
core
Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Although sequencing of ribosome footprints has uncovered aspects of mRNA translation, the determinants of ribosome flux remain incompletely understood.
A. Riba +5 more
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Thermodynamic and kinetic insights into stop codon recognition by release factor 1. [PDF]
, 2014 Stop codon recognition is a crucial event during translation termination and is performed by class I release factors (RF1 and RF2 in bacterial cells). Recent crystal structures showed that stop codon recognition is achieved mainly through a network of ...
Joseph, Simpson +2 more
core
Structural characterization of ribosome recruitment and translocation by type IV IRES
eLife, 2016 Viral mRNA sequences with a type IV IRES are able to initiate translation without any host initiation factors. Initial recruitment of the small ribosomal subunit as well as two translocation steps before the first peptidyl transfer are essential for the ...
Jason Murray +5 more
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