Results 181 to 190 of about 406,930 (327)
Advanced Science, EarlyView.This study presents the sono‐sensitive nanorobot Sono@NAT10, which targets NAT10 condensates to reprogram tumor‐associated macrophages in colorectal cancer. By reducing the acetylation level of SRSF2 protein and activating HDAC10, Sono@NAT10 promotes M1 polarization, suppresses tumor progression, and strengthens immunotherapy. The approach demonstrates
Jiahao Zhu +11 more
wiley +1 more source
The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome–nascent chain complex [PDF]
, 1998 Christine Pfund +7 more
openalex +1 more source
Advanced Science, EarlyView.Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou +13 more
wiley +1 more source
Investigating the entire course of telithromycin binding to Escherichia coli ribosomes [PDF]
, 2012 Ourania N. Kostopoulou +4 more
openalex +1 more source
Mechanisms and functions of ribosome-associated protein quality control
Nature reviews. Molecular cell biology, 2019 C. Joazeiro
semanticscholar +1 more source
Advanced Science, EarlyView.This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao +20 more
wiley +1 more source
SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations [PDF]
, 2015 Akira Okano +5 more
openalex +1 more source
Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders
Advanced Science, EarlyView.This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin +8 more
wiley +1 more source
Photoaffinity polyamines: interactions with AcPhe-tRNA free in solution or bound at the P-site of Escherichia coli ribosomes [PDF]
, 2000 Ioannis Amarantos
openalex +1 more source
Advanced Science, EarlyView.ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang +6 more
wiley +1 more source