Results 261 to 270 of about 406,930 (327)

Method Overview for Discovering ATE1 Substrates and their Arginylation Sites

open access: yesChemBioChem, EarlyView.
Arginylation is a decades‐old post‐translational modification but is inherently difficult to study. A plurality of methods have been developed and deployed to uncover the biology and substrates of this modification. This review covers the history, major advancements, and substrates discovered over the course of six decades.
Richard M. Searfoss   +2 more
wiley   +1 more source

Ribosomal proteins: functions beyond the ribosome.

open access: yesJournal of Molecular Cell Biology, 2015
Xiaoping Zhou   +4 more
semanticscholar   +1 more source

TRiC Is a Structural Component of Mammalian Sperm Axonemes

open access: yesCytoskeleton, EarlyView.
ABSTRACT The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo‐electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial ...
Alan Brown   +3 more
wiley   +1 more source

Fluorescent Dyes for Probing Intracellular and Subcellular Polarity

open access: yesChemistry–Methods, EarlyView.
Fluorescent probes are crucial tools for measuring cellular microenvironment polarity, a parameter that influences physiological organelle function and diseases such as cancer. This text details the probes' physicochemical principles, intracellular targeting strategies, and key photophysical parameters for polarity estimation.
M. Carmen Gonzalez‐Garcia   +4 more
wiley   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff   +6 more
wiley   +1 more source

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking. [PDF]

open access: yesNat Struct Mol Biol
Pellowe GA   +11 more
europepmc   +1 more source

Transcriptome-wide measurement of translation by ribosome profiling.

open access: yesMethods, 2017
Nicholas J. McGlincy   +1 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy