Results 281 to 290 of about 406,930 (327)

Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases: Exploring How Flawed Ribosome Recycling Factors Impact Ribosome Metabolism and Organelle Homeostasis, Leading to Human Diseases. [PDF]

Bioessays
Tahmasebinia F, Wu Z.
europepmc   +1 more source

Global Stress Responses Identify the Functionally Divergent Regulators Required for Candida auris Commensalism and Pathogenicity

Exploration, EarlyView.
Candida auris is an emerging multidrug‐resistant fungal pathogen that poses a serious global health threat. In our study, we comprehensively delineate both the pan‐genomic and transcriptomic features of C. auris. Intriguingly, our findings reveal an unexpected alkaline pH‐dependent regulation required for C. auris virulence and commensalism mediated by
Chaoyue Xu, Wanxing Xu, Yushun Yuan, Xiaoqing Chen, Ouyang Mo, Zhe Yin, Xinhua Huang, Yuanyuan Wang, Lingfei Hu, Wenwen Xue, Yun Zou, Luyao Zhang, Kunlin Li, Yueru Tian, Jihong Liu, Sichu Xiong, Lei Wu, Yanmei Dong, Guangsheng Chen, Yuping Zhang, Zili Zhou, Ming Guan, Xiaotian Huang, Zhiyi He, Lin Zhong, Lingbing Zeng, Pei Hao, Xiaoqi Zheng, Changbin Chen, Ning‐Ning Liu, Dongsheng Zhou   +30 more
wiley   +1 more source

The intrinsic properties of mRNAs define their translation efficiency at ribosome shortage. [PDF]

Nucleic Acids Res
Babaylova ES, Gopanenko AV, Tupikin AE, Kabilov MR, Malygin AA.   +4 more
europepmc   +1 more source

Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C‐Mediated SMAD3 mRNA Stability

Exploration, EarlyView.
This study demonstrates that elevated N‐acetyltransferase 10 (NAT10) expression stabilizes SMAD3 mRNA through ac4C modification, promoting the progression of hepatocellular carcinoma (HCC). NAT10 also activates the TGF‐β signaling pathway, facilitating epithelial‐to‐mesenchymal transition and inhibiting anoikis. Furthermore, the authors develop a small‐
Yigan Zhang, Yanbin Dong, Shuwen Chen, Hao Deng, Weiru Yu, Bonan Chen, Minjie Chen, Wanglong Liu, Xiao Tan, Jiaxin Ni, Daniel Rigden, Xuan Wang, Wuhua Zhou, Jia Meng, Juan Chen, Yuanchao Xue, Zhongji Meng   +16 more
wiley   +1 more source

Multifaceted roles of mycobacterial HflX: ribosome splitting, rRNA disordering, and drug resistance. [PDF]

Biochem Soc Trans
Majumdar S, Ghosh P, Agrawal RK.
europepmc   +1 more source

Modulation of Gut Microbiota by Protein‐Oligosaccharide Maillard‐Reaction‐Derived Probiotic Microcapsules

Food Bioengineering, EarlyView.
Development of a novel synbiotic microcapsule and its impact on gut microbiota. ABSTRACT As a new type of prebiotic, the Maillard reaction products of protein ‐ oligosaccharide conjugates have emerged as a promising material for probiotic encapsulation and improve host health.
Hongxing Zhang, Yue Shen, Wanting Huang, Xinyi Fang, Yanlin Wang, Xingyuan Ma, Wenyun Zheng   +6 more
wiley   +1 more source

Truncated and Disubstituted (P4K and L7R) Oncocin Peptides Target the Ribosome with Improved Antibacterial Activity. [PDF]

ACS Omega
Wolak T, Islam R, Venneti NM, Stockdill JL, Nguyen HM, Chow CS.   +5 more
europepmc   +1 more source

Development of Komagataella phaffii Cell‐Free Protein Synthesis Using Cell From Basic Salt Medium

Food Bioengineering, EarlyView.
This process illustrates a three‐step procedure for K. phaffii CFPS setup. First, K. phaffii cells are cultivated in basic salt medium and harvested by centrifugation. Then, cell extract is prepared from cell pellets through ultrasonic disruption, dialysis, centrifugation, and lyophilisation. Finally, K.
Yu Zhang, Yue Wang, Wenjie Cong, Hualan Zhou, Jianguo Zhang   +4 more
wiley   +1 more source

Cryo-EM structure of ribosome from pathogenic protozoa Entamoeba histolytica reveals unique features of its architecture. [PDF]

Nat Commun
Sharma S, Mishra S, Gourinath S, Kaushal PS.   +3 more
europepmc   +1 more source

High‐Dose Parenteral Iron Corrects Iron Deficiency Anemia While Disrupting Gut Microbiota and Metabolic Homeostasis in Neonatal Piglets

Food Frontiers, EarlyView.
Our results indicate that although high‐dose parenteral iron effectively corrects iron deficiency anemia (IDA), it causes liver dysfunction, immune suppression, systemic iron overload, and altered gut microbiota. ABSTRACT Iron deficiency anemia (IDA) is a common nutritional disorder in mammals, particularly affecting neonates and neonatal piglets ...
Qian Zhang, Yubin Hao, Xin Tian, Xuejiao Li, Jie Feng   +4 more
wiley   +1 more source