Results 281 to 290 of about 343,033 (331)

Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition

PROTEOMICS, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq, Alin Rai, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, David W. Greening, Richard J. Simpson   +6 more
wiley   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline

Stuart WS, Isupov MN, McLaren M, Jenkins CH, Monier A, Daum B, Norville IH, Gold VA, Harmer NJ.   +8 more
europepmc   +1 more source

Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk. [PDF]

Nat Commun
Liang Q, Jiang Y, Shieh AW, Zhou D, Chen R, Wang F, Xu M, Niu M, Wang X, Pinto D, Wang Y, Cheng L, Vadukapuram R, Zhang C, Grennan K, Giase G, White KP, Peng J, Li B, Liu C, Chen C, Wang SH.   +21 more
europepmc   +1 more source

Secrets within stems: The cryptic Apodanthes caseariae (Apodanthaceae), a rare neotropical holoendoparasite

PLANTS, PEOPLE, PLANET, EarlyView.
Holoendoparasites are extremely rare plants that live entirely hidden inside their hosts, with only flowers and fruits visible. We studied Apodanthes caseariae, found in central and South America, parasitizing Casearia sylvestris. Little is known about its life cycle.
Jessica A. Ramírez‐Ramírez, Favio González, Estefanía Elejalde‐Baena, Juan F. Alzate, Natalia Pabón‐Mora   +4 more
wiley   +1 more source

eIF2D promotes 40S ribosomal subunit recycling during intrinsic ribosome destabilization. [PDF]

Nucleic Acids Res
Ichihara K, Shiraishi T, Chadani Y, Kito Y, Shiraishi C, Hirata M, Takahashi Y, Kobo A, Hatano A, Matsumoto M, Machida K, Imataka H, Toyoda A, Mishiro-Sato E, Nojima T, Ito T, Taguchi H, Nakayama KI, Matsumoto A.   +18 more
europepmc   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

A conserved C2H2 zinc finger protein, Rel1, links ribosome biogenesis to sexual development and antifungal susceptibility in a ubiquitous human fungal pathogen. [PDF]

Appl Environ Microbiol
Yan L, Chen M, Liu Y, Hu P, Wang Y, Cao Y, Huang Y, Tian X, Xu X, Zheng F.   +9 more
europepmc   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

METTL5 in physiology and pathology: mechanisms and implications. [PDF]

Front Cell Dev Biol
Li C, Jiang X, Yuan Y, Wang Q.
europepmc   +1 more source