Results 301 to 310 of about 406,930 (327)

ER biogenesis without stress: how the ribosome receptor, p180, defines a developmental program beyond the UPR. [PDF]

Front Cell Dev Biol
Benyamini P, Meyer DI.
europepmc   +1 more source

Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A‐YTHDF2‐dependent mechanism

iMeta, EarlyView.
Homoharringtonine (HHT), a clinically approved anti‐leukemic drug, directly binds the RNA‐binding protein EWSR1. HHT induces an allosteric conformational switch in the RNA recognition motif of EWSR1, driving self‐association and liquid–liquid phase separation (LLPS). The resulting condensates act as regulatory hubs that sequester the m6A reader YTHDF2,
Ting‐Ting Liu, Li‐Ting Chen, Xu‐Ying Pei, Shao‐Nan Hu, Fang‐Fang Zhuo, Ze‐Kun Chen, Yang Liu, Jing‐Kang Wang, Ji‐Chao Zhang, Qi Cao, Ling Li, Jing Wang, Tian‐Tian Wei, Bo Han, Peng‐Fei Tu, Xiang‐Yu Zhao, Ruidong Xue, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Near-cognate tRNAs dominate codon decoding times in simulated ribosomes. [PDF]

Nucleic Acids Res
Hedayioglu F, Hargreaves EJ, Kurusamy S, Thaventhiran JED, Willis AE, Smales CM, von der Haar T.   +6 more
europepmc   +1 more source

Single‐nucleus RNA sequencing reveals RUNX1 regulation of muscle hypertrophy through PI3K/AKT/mTOR pathway

iMeta, EarlyView.
We used snRNA‐seq to construct a high‐resolution atlas of pectoral muscle development in broiler chickens from neonatal to adult stages. This analysis revealed pronounced molecular heterogeneity among satellite cells across developmental phases and uncovered a previously uncharacterized Runx1+ satellite cell subpopulation.
Chenxu Wang, Junjie Ma, Yibin Wang, Rui Liu, Chenxi Zhang, Qingyuan Li, Lixin Zhang, Qihang Hou, Xiaojun Yang   +8 more
wiley   +1 more source

Anticancer drug development against ribosome synthesis and the nucleolus. [PDF]

Biochem Soc Trans
Loiacono A, Huang S.
europepmc   +1 more source

Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity

Teresa M. Lamb, Kathrina Castillo, Rachel Porter, Cheng Wu, Samuel Purvine, Griffin Best, Erika Zink, Ebimobowei O. Preh, Lunda Shen, Matthew S. Sachs, Deborah Bell‐Pedersen   +10 more
openalex   +1 more source

A Multimodal Approach to Identify Metallothionein Metal Inducers in Nile Tilapia: Insights From Molecular Docking and Hepatocyte Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT Many human activities contribute to the pollution of aquatic ecosystems, primarily through agricultural, industrial, mining, and domestic discharges into water bodies. Fish, being highly sensitive to environmental changes, serve as valuable models for monitoring the health of these ecosystems.
Jessica Zablocki da Luz, Tugstênio Lima de Souza, Aliciane de Almeida Roque, Micheli de Marchi, Roberta Pozzan, Camila Confortin, Iracema Opuskevitch, Fernando Cesar Alves da Silva Ferreira, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +9 more
wiley   +1 more source

Effects of light on chloroplast translation in Marchantia polymorpha are similar to those in angiosperms and are not influenced by light-independent chlorophyll synthesis. [PDF]

Plant J
Chotewutmontri P, Williams-Carrier R, Belcher S, Barkan A.   +3 more
europepmc   +1 more source

Phasins PhbP2 and PhbP3 Are Involved in the Depolymerization of Polyhydroxybutyrate in Azotobacter vinelandii

Journal of Basic Microbiology, EarlyView.
ABSTRACT Polyhydroxybutyrate (PHB) is a natural polyester synthesized and stored intracellularly as cytoplasmic granules, serving as a carbon and energy reserve in certain bacteria. These granules are surrounded by a variety of proteins, including those directly involved in PHB metabolism—both in its synthesis and degradation—as well as a group of non ...
Jessica Ruiz‐Escobedo, Josefina Guzmán, Guadalupe Espín, Thalía Barrientos‐Millán, Andrea Moyao‐Mejía, Carlos Peña, Soledad Moreno, Erika P. Meneses‐Romero, Daniel Segura   +8 more
wiley   +1 more source

CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma. [PDF]

Cell Rep
Chadourne M, Griffith C, Jasani N, Xu X, Brennan E, Vera O, Mecozzi N, Wang K, Jaeger AM, Karreth FA.   +9 more
europepmc   +1 more source