Results 141 to 150 of about 173,360 (283)

Single‐Cell RNA Sequencing Identifies Accumulation of Fcgr2b + Virtual Memory‐Like CD8 T Cells With Cytotoxic and Inflammatory Potential in Aged Mouse White Adipose Tissue

Aging Cell, EarlyView.
Age‐associated accumulation of Fcgr2b + VM‐like CD8 T cells within visceral adipose tissue contributes to inflammation. ABSTRACT Aging and obesity are associated with pro‐inflammatory changes in adipose tissue. Overlapping mechanisms, such as the infiltration of inflammatory macrophages and T cells into visceral adipose tissue, have been implicated in ...
Archit Kumar, Martin O'Brien, Vincent B. Young, Raymond Yung   +3 more
wiley   +1 more source

circUBR5 promotes ribosome biogenesis and induces docetaxel resistance in triple-negative breast cancer cell lines via the miR-340-5p/CMTM6/c-MYC axis

Neoplasia: An International Journal for Oncology Research
Objective: Docetaxel (DTX) represents an effective chemotherapeutic agent for treating triple-negative breast cancer (TNBC), but the efficacy is strongly limited by drug resistance.
Xuedong Wang, Xinping Wang, Juan Gu, Yilei Wei, Yueping Wang   +4 more
doaj   +1 more source

Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

Aging Cell, EarlyView.
Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio, Christina Dimovasili, Yuchen Liu, Bingtian Ye, Jou‐Hsuan Roxie Lee, Molly Hartigan, Benjamin Bouchard, Madelyn Ray, Bryce Conner, Kelli L. Vaughan, Julie A. Mattison, Tara L. Moore, Chao Zhang, Douglas L. Rosene   +13 more
wiley   +1 more source

Oocyte Age‐Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes

Aging Cell, EarlyView.
As females age, oocyte chromosomal aberrations and DNA damage increase in frequency; this condition is believed to be irreversible. By exposing the aged oocyte nuclei to nuclear factors from young oocytes, the negative effects can be effectively suppressed, restoring their developmental competence. ABSTRACT Mammalian fully grown oocytes are believed to
Nataliia Dudko, Tereza Ilcikova, Natalie Novotna, Marta Czernik, Pasqualino Loi, Josef Fulka Jr., Pritha Bhattacharjee, Raffaella Santoro, Helena Fulka   +8 more
wiley   +1 more source

Regulation of ribosome biogenesis by TOR complex 1 kinase and transcription factor Sfp1

, 2009
Harri Lempiäinen
openalex   +1 more source

NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling [PDF]

, 2011
Mikael S. Lindström
openalex   +1 more source

Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells [PDF]

, 2020
Maria Dermit, Martin Dodel, Flora Lee, Muhammad S. Azman, Hagen Schwenzer, J. Louise Jones, Sarah P. Blagden, Jernej Ule, Faraz K. Mardakheh   +8 more
openalex   +1 more source

Comparative metabolomic and transcriptomic analysis of 2D and 3D mesenchymal stem cell cultures for improved therapeutic applications

British Journal of Pharmacology, EarlyView.
Comparative metabolomic and transcriptomic profiling reveals distinct metabolic shifts and reduced proliferation in 3D MSC spheroids, providing insights to optimise MSC‐based therapies. Abstract Background and Purpose Mesenchymal stem cells (MSCs) are used widely in regenerative medicine due to their multipotency and immunomodulatory properties ...
Manju Shrestha, Yun‐Seo Kil, Yunju Jo, Simmyung Yook, Ki Hyun Kim, Dongryeol Ryu, Joo‐Won Nam, Jee‐Heon Jeong   +7 more
wiley   +1 more source

Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy [PDF]

, 2015
Vandré C. Figueiredo, Marissa K. Caldow, Vivien Massie, James F. Markworth, David Cameron‐Smith, Anthony J. Blazevich   +5 more
openalex   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source