Results 151 to 160 of about 142,894 (282)

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source

Illuminating ribosome biogenesis disorders through structural biology. [PDF]

RNA Biol
Singh S, Lafontaine DLJ.
europepmc   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Mechanisms regulating ribosome biogenesis by AKT

, 2015
© 2015 Dr. Simone Jacinta WoodsRibosomes are essential for cell growth and proliferation, and their biogenesis is a highly energy consuming process that requires exquisite regulation.
Woods, Simone Jacinta
core   +1 more source

Granular component sub-phases direct ribosome biogenesis in the nucleolus. [PDF]

Mol Cell
Dogra P, Ferrolino MC, Khatun S, Miao Q, Tolbert M, Pitre A, Pruett-Miller SM, Tripathi S, Baggett DW, John J, Campbell GE, Jackson K, Bajpai R, Freyaldenhoven T, Gibbs E, Park CG, Kriwacki RW.   +16 more
europepmc   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

NOC4L coordinates neuronal and pharyngeal arch development by regulating ribosome biogenesis. [PDF]

J Mol Cell Biol
Song T, Liu Y, Zhou Y, Li X, Zhang L, Ning G, Zhang J.   +6 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1-Regulated Ribosome Biogenesis. [PDF]

Adv Sci (Weinh)
Li M, Wu Y, Zhou S, Tang P, Wei J, Liu L, Wang Z, Shi D, Yuan S, Zhang Q, Wang S, Zhang Q, Zhao H, Zhang R, Wang Y, Yang S, Chen X, Shi X, Liu G, Zhang Y, Li J, Zhang XD, Thorne RF, Wei D, Zhu Z, Chen S.   +25 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source