Results 151 to 160 of about 173,360 (283)

Data from BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma

, 2023
Keiji Kurata, Mehmet Samur, Priscilla Liow, Kenneth Wen, Leona Yamamoto, Jiye Liu, Eugenio Morelli, Annamaria Gullà, Yu‐Tzu Tai, Jun Qi, Teru Hideshima, Kenneth C. Anderson   +11 more
openalex   +1 more source

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, EarlyView.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Serial Analysis of Gene Expression Reveals Conserved Links between Protein Kinase A, Ribosome Biogenesis, and Phosphate Metabolism in Ustilago maydis

, 2005
Luis Larraya, Kylie J. Boyce, Austin P. So, Barbara R. Steen, Steven J.M. Jones, Marco A. Marra, James W. Kronstad   +6 more
openalex   +1 more source

CHLOROPLAST RIBOSOME BIOGENESIS IN CHLAMYDOMONAS [PDF]

, 1974
Elizabeth H. Harris, John E. Boynton, Nicholas W. Gillham   +2 more
openalex   +1 more source

Tumor‐Derived Prostaglandin E2 Promotes Colorectal Cancer Progression by Inducing N2‐Type TAN Polarization

Cancer Science, EarlyView.
We demonstrated that PGE2 released from LDs in CRC cells plays important roles in N2‐type TANs polarization. PGE2 enters neutrophils through its receptor EP2/EP4 to stimulate ROS‐mediated FOXO3a methylation, thereby increasing the polarization of N2‐type TANs.
Yue Han, Wen Chen, Bin Zhang, Shuang Wang   +3 more
wiley   +1 more source

Chemical Inhibition of Bacterial Ribosome Biogenesis Shows Efficacy in a Worm Infection Model [PDF]

, 2015
Jonathan Stokes, Carrie Selin, Silvia T. Cardona, Eric D. Brown   +3 more
openalex   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA [PDF]

, 2010
Britta Meyer, Jan Philip Wurm, Peter Kötter, Matthias S. Leisegang, Valeska Schilling, Markus Buchhaupt, Martin Held, U. Bahr, Michael Karas, Alexander Heckel, Markus T. Bohnsack, Jens Wöhnert, Karl‐Dieter Entian   +12 more
openalex   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis.

PLoS Biology
Cancer initiates as a consequence of genomic mutations and its subsequent progression relies in part on increased production of ribosomes to maintain high levels of protein synthesis for unchecked cell growth.
Mason A McCool, Carson J Bryant, Laura Abriola, Yulia V Surovtseva, Susan J Baserga   +4 more
doaj   +1 more source