Results 151 to 160 of about 88,539 (283)

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, EarlyView.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy [PDF]

, 2015
Vandré C. Figueiredo, Marissa K. Caldow, Vivien Massie, James F. Markworth, David Cameron‐Smith, Anthony J. Blazevich   +5 more
openalex   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis.

PLoS Biology
Cancer initiates as a consequence of genomic mutations and its subsequent progression relies in part on increased production of ribosomes to maintain high levels of protein synthesis for unchecked cell growth.
Mason A McCool, Carson J Bryant, Laura Abriola, Yulia V Surovtseva, Susan J Baserga   +4 more
doaj   +1 more source

Chemical Inhibition of Bacterial Ribosome Biogenesis Shows Efficacy in a Worm Infection Model [PDF]

, 2015
Jonathan Stokes, Carrie Selin, Silvia T. Cardona, Eric D. Brown   +3 more
openalex   +1 more source

Meioc-Piwil1 Complexes Regulate Ribosome Biogenesis for the Differentiation of Germline Stem Cells

, 2022
Toshihiro Kawasaki, T. Nishimura, Naoki Tani, Carina Ramos, Emil Karaulanov, Minori Shinya, Kenji Saito, Emily Taylor, René F. Ketting, Kei‐ichiro Ishiguro, Minoru Tanaka, Kellee R. Siegfried, Noriyoshi Sakai   +12 more
openalex   +1 more source

Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET [PDF]

, 2023
Dimitris C. Kanellis, Asimina Zisi, Zdeněk Škrott, Bennie Lemmens, Jaime A. Espinoza, Martin Košař, Andrea Björkman, Xuexin Li, Stefanos Arampatzis, Jiřina Bártková, Miguel Andújar, Óscar Fernández-Capetillo, Martin Mistrík, Mikael S. Lindström, Jiří Bártek   +14 more
openalex   +1 more source

GeARF5/GeIAA33‐GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata

Journal of Integrative Plant Biology, EarlyView.
Auxin signaling regulates the formation of vegetative propagation corms in Gastrodia elata by regulating sugar‐acid interconversion, which in turn regulates polysaccharide and starch biosynthesis as well as biosynthesis of the bioactive metabolite gastrodin.
Qun Liu, Zhiqing Wu, Yugang Gao, Yue Xu, Pu Zang, Xinyu Yang, Yan Zhao, Pan Liao, Benoît Boachon, Guoyin Kai   +9 more
wiley   +1 more source

NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling [PDF]

, 2011
Mikael S. Lindström
openalex   +1 more source

Consecutive Steps of Nucleoside Triphosphate Hydrolysis Are Driving Transport of Precursor Proteins into the Endoplasmic Reticulum [PDF]

, 1992
Klappa, Peter, Lill, Roland, Müller, Günter, Neupert, Walter, Schlenstedt, Gabriel, Wiech, Hans, Zimmermann, Richard   +6 more
core   +1 more source