Results 181 to 190 of about 3,389,294 (250)
The FEBS Journal, Volume 293, Issue 18, Page 5585-5599, September 2026.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. [PDF]
Chem Commun (Camb), 2017 Roy S +9 more
europepmc +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Optimization of EnBase Fed-Batch Cultivation to Improve Soluble Fraction Ratio of α-Luffin Ribosome Inactivating Protein. [PDF]
Iran J Biotechnol, 2018 Barkhordari F +4 more
europepmc +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, Volume 293, Issue 18, Page 5627-5644, September 2026.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
Immunology, Volume 179, Issue 1, Page 54-71, September 2026.Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo +7 more
wiley +1 more source
Cleavage of nicotinamide adenine dinucleotide by the ribosome-inactivating protein from Momordica charantia. [PDF]
Acta Crystallogr F Struct Biol Commun, 2015 Vinkovic M +5 more
europepmc +1 more source