Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer [PDF]
Scientific Reports, 2017 Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA.
Walter J. Lapadula +4 more
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Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells [PDF]
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rossella Rotondo +7 more
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Overexpression of the ribosome-inactivating protein OsRIP1 modulates the jasmonate signaling pathway in rice [PDF]
Frontiers in Plant ScienceRibosome-inactivating proteins (RIPs) are plant enzymes that target the rRNA. The cytoplasmic RIP, called OsRIP1, plays a crucial role in regulating jasmonate, a key plant hormone.
Simin Chen +10 more
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Ribosome Inactivating Proteins: From Plant Defense to Treatments against Human Misuse or Diseases [PDF]
Toxins, 2018 Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae, and bacteria. RIP activities have also been detected in animal tissues.
Julien Barbier, Daniel Gillet
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Primary Sequence and Three-Dimensional Structural Comparison between Malanin and Ricin, a Type II Ribosome-Inactivating Protein [PDF]
ToxinsMalanin is a new type II ribosome-inactivating protein (RIP) purified from Malania oleifera, a rare, endangered tree is only found in the southwest of Guangxi Province and the southeast of Yunnan Province, China.
Yan Yuan, Shuxiao Wu, Philip J. R. Day
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Revising the taxonomic distribution, origin and evolution of ribosome inactivating protein genes. [PDF]
PLoS ONE, 2013 Ribosome inactivating proteins are enzymes that depurinate a specific adenine residue in the alpha-sarcin-ricin loop of the large ribosomal RNA, being ricin and Shiga toxins the most renowned examples.
Walter J Lapadula +2 more
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Structure of Ribosome-Inactivating Protein from Mirabilis jalapa and Its L12-Stalk-Dependent Inhibition of Escherichia coli Ribosome [PDF]
ToxinsMirabilis antiviral protein (MAP) is the type I ribosome-inactivating protein (RIP), which consists of an RNA N-glycosylase domain with no carbohydrate-binding domain.
Nanami Nishida +7 more
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Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein [PDF]
Toxins, 2018 Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA).
Wei-Wei Shi, Kam-Bo Wong, Pang-Chui Shaw
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Anti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmin 1 [PDF]
Toxins, 2016 Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature.
Begoña Barriuso +7 more
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Recombinant tritin protein exhibits antiviral activity against zucchini yellow mosaic virus [PDF]
BMC Plant BiologyBackground Ribosome-inactivating proteins (RIPs) are a group of proteins known to inhibit protein synthesis and contribute to plant defense responses. Although the antiviral properties of various RIPs have been demonstrated, the antiviral potential of ...
Serap Demi̇rel +3 more
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