Ribosome Inactivating Proteins from Rosaceae [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) are widespread among higher plants of different taxonomic orders. In this study, we report on the RIP sequences found in the genome/transcriptome of several important Rosaceae species, including many economically important edible fruits such as apple, pear, peach, apricot, and strawberry.
Chenjing Shang +2 more
openalex +7 more sources
A Sixty-Year Research and Development of Trichosanthin, a Ribosome-Inactivating Protein. [PDF]
Toxins (Basel), 2022 Tian Hua Fen, a herbal powder extract that contains trichosanthin (TCS), was used as an abortifacient in traditional Chinese medicine. In 1972, TCS was purified to alleviate the side effects.
Lu JQ, Wong KB, Shaw PC.
europepmc +2 more sources
Recombinant anti-HIV MAP30, a ribosome inactivating protein: against plant virus and bacteriophage. [PDF]
Sci Rep, 2023 The ribosome inactivating proteins (RIPs) efficiently decrease the microbial infections in plants. Momordica charantia MAP30 is a type I RIP that has not been investigated against plant viruses or bacteriophages.
Amirzadeh N +3 more
europepmc +2 more sources
In-silico analysis of ribosome inactivating protein (RIP) of the Cucurbitaceae family. [PDF]
AMB ExpressRibosome-inactivating proteins (RIPs) are highly active N-glycosidases that depurinate both bacterial and eukaryotic rRNAs, halting protein synthesis during translation.
Maqsood Q +5 more
europepmc +2 more sources
Structure and Activity of a Cytosolic Ribosome-Inactivating Protein from Rice. [PDF]
Toxins (Basel), 2019 Ribosome-inactivating proteins (RIPs) are cytotoxic enzymes that inhibit protein translation by depurinating ribosomal RNA. Although most plant RIPs are synthesized with leader sequences that sequester them away from the host ribosomes, several RIPs from
De Zaeytijd J +3 more
europepmc +2 more sources
Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects. [PDF]
Toxins (Basel), 2015 Viruses employ an array of elaborate strategies to overcome plant defense mechanisms and must adapt to the requirements of the host translational systems. Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome inactivating protein (RIP)
Domashevskiy AV, Goss DJ.
europepmc +2 more sources
Crystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2. [PDF]
Toxins (Basel), 2016 Ricin is a type 2 ribosome-inactivating protein (RIP), containing a catalytic A chain and a lectin-like B chain. It inhibits protein synthesis by depurinating the N-glycosidic bond at α-sarcin/ricin loop (SRL) of the 28S rRNA, which thereby prevents the ...
Shi WW +5 more
europepmc +2 more sources
Antiviral Activity of Ribosome-Inactivating Proteins [PDF]
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the ...
Citores González, Lucía +2 more
openaire +4 more sources
Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer. [PDF]
Sci Rep, 2017 Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA.
Lapadula WJ +4 more
europepmc +2 more sources
The recombinant maize ribosome-inactivating protein transiently reduces viral load in SHIV89.6 infected Chinese Rhesus Macaques. [PDF]
Toxins (Basel), 2015 Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation
Wang RR +13 more
europepmc +2 more sources