Results 101 to 110 of about 35,431,844 (244)

Ribosome‐Inactivating Proteins (RNA N‐glycosidases) from the Seeds of Saponaria ocymoides and Vaccaria pyramidata

, 1995
From the seeds of the Caryophyllaceae Saponaria ocymoides and Vaccaria pyramidata two proteins were purified which have the properties of the type-1 (single-chain) ribosome-inactivating proteins [reviewed by Barbieri, L., Battelli, M. G. & Stirpe, F.
Parente A., Del Vecchio Blanco F., Olivieri F., Barbieri L., Bolognesi A., Falasca A. I., Stirpe F., Battelli M. G.   +7 more
core   +1 more source

Yeast Knockout Strain Collection: Driving Functional Genomics, Biotechnological Applications and Human Disease Research

Yeast, EarlyView.
ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley   +1 more source

Cellular mechanism of the neurotoxicity of ribosome-inactivating proteins. [PDF]

, 2001
by Wai-Man Tong.Thesis (M.Phil.)--Chinese University of Hong Kong, 2001.Includes bibliographical references (leaves 155-174).Abstracts in English and Chinese.ABSTRACT --- p.I-IVChapter 1. --- INTRODUCTIONChapter 1.1.

core  

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Ribosome-inactivating proteins

, 2005
The known toxic and non-toxic ribosome-inactivating proteins are listed and classified and their nature, distribution mechanism of action and other properties are described.
STIRPE, FIORENZO
core  

Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: Effect on DNA, RNA and poly(A)

, 1997
Ribosome-inactivating proteins (RIP) are a family of plant enzymes for which a unique activity was determined: rRMA N-glycosidase at a specific universally conserved position, A4324 in the case of rat ribosomes.
Valbonesi P., Barbieri L., Gorini P., Bolognesi A., Bonora E., Stirpe F.   +5 more
core   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Antifungal activity of ribosome-inactivating proteins [PDF]

Producción CientíficaThe control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly.
Gay, Claudia C., Lucía Citores, Citores González, Lucía, Ferreras Rodríguez, José Miguel, Claudia C. Gay, Rosario Iglesias, Citores, Lucía, Gay, Claudia Carolina, Iglesias Álvarez, María del Rosario, José M. Ferreras, Ferreras, José M., Iglesias, Rosario   +11 more
core   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source