Results 41 to 50 of about 35,431,844 (244)
Bouganin, an Attractive Weapon for Immunotoxins
Toxins, 2018 Bougainvillea (Bougainvillea spectabilis Willd.) is a plant widely used in folk medicine and many extracts from different tissues of this plant have been employed against several pathologies.
Massimo Bortolotti +2 more
doaj +1 more source
Ribosome-inactivating proteins [PDF]
, 2013 Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis.
Dodd, J.E. +2 more
core +1 more source
Type 1 ribosome-inactivating proteins depurinate plant 25S rRNA without species specificity
Nucleic Acids Research, 1992 Four different type 1 ribosome-inactivating proteins (RIPs) with RNA N-glycosidase activity were tested for their ability to attack the large rRNA of plant ribosomes derived from tobacco plants, as well as from the plant species from which the particular RIP had been isolated.
J, Prestle +3 more
openaire +3 more sources
Structure and Activity of a Cytosolic Ribosome-Inactivating Protein from Rice
Toxins, 2019 Ribosome-inactivating proteins (RIPs) are cytotoxic enzymes that inhibit protein translation by depurinating ribosomal RNA. Although most plant RIPs are synthesized with leader sequences that sequester them away from the host ribosomes, several RIPs from
Jeroen De Zaeytijd +3 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Saporins - Type 1 Ribosome-inactivating proteins from soapwort (saponaria officinalis L.) [PDF]
, 1995 Ribosome-inactivating proteins (RlPs) are found distributed throughout the plant kingdom. These proteins possess a RNA N-glycosidase activity whereby the depurination of a specific adenine residue from the large ribosomal subunit renders eukaryotic and ...
Sinclair, Lesley Jean
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Gene sequences encoding ribosome-inactivating proteins from soapwort (Saponaria officinalis L.) [PDF]
, 1991 Ribosome-inactivating proteins (RIPs) are found in a wide variety of plant species. They possess an RNA N-glycosidase activity whereby the removal of a specific adenine residue from 28 S RNA renders a eukaryotic ribosome inactive.
Fordham-Skelton, Anthony P.
core
2A-induced ribosome stalling [PDF]
, 2014 Originally 2A was characterised in foot-and-mouth disease virus. Site directed mutagenesis identified a C-terminus consensus motif [D(V/I)ExNPGP] and it is proposed that 2A interacts with the exit tunnel of the ribosome in a way that a specific peptide ...
Odon, Valèrie
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source