Results 21 to 30 of about 35,431,844 (244)
Iris Bulbs Express Type 1 and Type 2 Ribosome-Inactivating Proteins with Unusual Properties [PDF]
Plant Physiology, 2001 Abstract Two closely related lectins from bulbs of the Dutch iris (Iris hollandica var. Professor Blaauw) have been isolated and cloned. Both lectins, called Iris agglutinin b and Iris agglutinin r, possess N-glycosidase activity and share a high sequence similarity with previously described type 2 ribosome-inactivating proteins (RIP ...
Q, Hao +6 more
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Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein [PDF]
Toxins, 2018 Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA). TCS has only one chain, and is classified as type 1 ribosome-inactivating protein (RIP). Our structural studies revealed that TCS consists of two domains, with five conserved catalytic residues Tyr70 ...
Wei-Wei Shi, Kam-Bo Wong, Pang-Chui Shaw
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X-ray sequence and crystal structure of luffaculin 1, a novel type 1 ribosome-inactivating protein [PDF]
BMC Structural Biology, 2007 Abstract Background Protein sequence can be obtained through Edman degradation, mass spectrometry, or cDNA sequencing. High resolution X-ray crystallography can also be used to derive protein sequence information, but faces the difficulty in distinguishing the Asp/Asn, Glu/Gln, and Val/Thr pairs. Luffaculin 1 is a new
Hou, Xiaomin +5 more
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2020 Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which is extracted from the seeds of castor beans. Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far.
Xu Zhao +7 more
doaj +1 more source
Food Chemistry, 2021 This study investigates on the presence of toxic proteins in quinoa seeds. To this aim, a plethora of biochemical approaches were adopted for the purification and characterization of quinoin, a type 1 ribosome-inactivating protein (RIP) contained in quinoa seeds.
Landi, Nicola +6 more
openaire +5 more sources
Biological Activities of Ribosome-Inactivating Proteins [PDF]
, 2023 After more than 50 years of research, studies on the structure and biological activities of ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the scientific community, both for the health risks they pose and their
Lucía Citores +5 more
core +1 more source
Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
Toxins, 2011 Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death.
Andrea Bolognesi +3 more
doaj +1 more source
Toxins, 2020 Using the pathosystem Phaseolus vulgaris–tobacco necrosis virus (TNV), we demonstrated that PD-L1 and PD-L4, type-1 ribosome inactivating proteins (RIPs) from leaves of Phytolacca dioica L., possess a strong antiviral activity.
Daniela Bulgari +4 more
doaj +1 more source
Pharmaceuticals, 2023 Multiple myeloma is a hematological malignancy characterized by the unrestricted proliferation of plasma cells that secrete monoclonal immunoglobulins in the bone marrow.
Zi-Wei Cai +9 more
doaj +1 more source
Impact of Mistletoe Triterpene Acids on the Uptake of Mistletoe Lectin by Cultured Tumor Cells. [PDF]
PLoS ONE, 2016 Complementary treatment possibilities for the therapy of cancer are increasing in demand due to the severe side effects of the standard cytostatics used in the first-line therapy.
Katharina Mulsow +5 more
doaj +1 more source