Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells [PDF]
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rossella Rotondo +7 more
doaj +11 more sources
Ebulitins: A new family of type 1 ribosome‐inactivating proteins (rRNA N‐glycosidases) from leaves of Sambucus ebulus L. that coexist with the type 2 ribosome‐inactivating protein ebulin 1 [PDF]
FEBS Letters, 1995 A new family of single chain (type 1) ribosome‐inactivating proteins (RIPs), that we have named ebulitins, have been found in mature leaves of Sambucus ebulus L., a caprifoliaceae plant also known to contain a non‐toxic two chain (type 2) RIP named ebulin 1 in its leaves.
de Benito, Fernando M. +7 more
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Biocontrol Potential of Sodin 5, Type 1 Ribosome-Inactivating Protein from Salsola soda L. Seeds
BiomoleculesSodin 5 is a type 1 ribosome-inactivating protein isolated from the seeds of Salsola soda L., an edible halophytic plant that is widespread in southern Europe, close to the coast.
Monika Novak Babič +8 more
doaj +4 more sources
Type 1 Ribosome-Inactivating Proteins from the Ombú Tree (Phytolacca dioica L.)
, 2010 The toxicity of plant proteins, later identified as ribosome-inactivating proteins (RIPs), was described more than a century ago and their enzymatic activity was established more than 30 years ago. However, their physiological role and related biological activities are still uncertain.
PARENTE A +3 more
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Molecularly imprinted polymers for protome analysis [PDF]
, 2008 Fast and efficient methods for the detection of insurgence and progression of diseases are at the basis of modern diagnostics and medicine. In this concern, biomarkers represent a powerful diagnostic tool, as their expression profiles well correlate ...
Bonini, Francesca
core +7 more sources
British Journal of Haematology, 2000 Immunotoxins specific for the CD80 and CD86 antigens were prepared by linking three type 1 ribosome‐inactivating proteins (RIPs), namely bouganin, gelonin and saporin‐S6, to the monoclonal antibodies M24 (anti‐CD80) and 1G10 (anti‐CD86). These immunotoxins showed a specific cytotoxicity for the CD80/CD86‐expressing cell lines Raji and L428.
Bolognesi A. +8 more
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Structure/funcion studies on type 1 ribosome inactivating proteins.
, 2008 Ribosome inactivating proteins (RIPs) are toxins, which depurinate major RNA inhibiting protein synthesis1. The cleaved N-glycosidic bond corresponds to a specific adenine located in the sarcin/ricin loop, highly conserved in rRNAs from different species and essential for interaction with elongation factors.
FERMANI, SIMONA +8 more
core +3 more sources
Comparison of the Embryotoxic Effects of Saporin, Agrostin (Type 1 Ribosome-Inactivating Proteins) and Ricin (a Type 2 Ribosome-Inactivating Protein [PDF]
Pharmacology and Toxicology, 2001 Abstract: The effects of two type I ribosome‐inactivating proteins, saporin and agrostin, and the type 2 ribosome‐inactivating protein ricin and its constituent A and B chains, on the development of cultured mouse embryos, were investigated. Saporin and agrostin had similar embryotoxicity which was approximately 105 times weaker than that of ricin and ...
W Y, Chan, T B, Ng
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Sensitivity of Translation byBrevibacterium lactofermentumRibosomes to Type 1 and Type 2 Ribosome-inactivating Proteins [PDF]
Bioscience, Biotechnology, and Biochemistry, 1994 An active cell-free translation system was prepared from Brevibacterium lactofermentum, a Gram-positive bacteria used in molecular cloning and protein expression. The system contained high speed postribosomal supernatant (S 370), purified ribosomes and a tRNA mixture from Escherichia coli, and synthesized polyuridylic acid-directed polyphenylalanine ...
Ferreras Miguel, Jose +3 more
openaire +2 more sources
Molecular action of the type 1 ribosome‐inactivating protein saporin 5 on Vicia sativa ribosomes [PDF]
FEBS Letters, 1993 The type 1 ribosome‐inactivating protein (RIP) saporin 5 isolated from seeds of Saponaria officinalis L. strongly inhibited translation carried out by Vicia sativa L. purified ribosomes. The toxin multidepurinated V. sativa rRNA, which upon treatment with acid aniline releases several RNA fragments including an RNA fragment of approximately 370 ...
Iglesias, Rosario +5 more
openaire +3 more sources