Results 51 to 60 of about 21,283 (123)

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme. [PDF]

open access: yes, 2016
Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome ...
Fujimori, Danica Galonić   +3 more
core  

Synthetic biology—putting engineering into biology [PDF]

open access: yes, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core   +1 more source

Two complementary approaches for intracellular delivery of exogenous enzymes. [PDF]

open access: yes, 2015
Intracellular delivery of biologically active proteins remains a formidable challenge in biomedical research. Here we show that biomedically relevant enzymes can be delivered into cells using a new DNA transfection reagent, lipofectamine 3000, allowing ...
Abbas, S.A.   +9 more
core   +1 more source

MTOR cross-talk in cancer and potential for combination therapy [PDF]

open access: yes, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C.   +7 more
core   +3 more sources

Ricinus Agglutinin Induced Autophagy in Glioblastoma Cells [PDF]

open access: yes, 2015
Ricinus agglutinin (RA) is a heterodimer consisting of two chains known as chain A and chain B respectively. The molecular weight of RA is 120 kD. RA is highly toxic to normal cells due to its ability to bind to the carbohydrate moieties present on the ...
Sahoo, puja
core  

Mining the bitter melon (momordica charantia l.) seed transcriptome by 454 analysis of non-normalized and normalized cDNA populations for conjugated fatty acid metabolism-related genes [PDF]

open access: yes, 2010
Background Seeds of Momordica charantia (bitter melon) produce high levels of eleostearic acid, an unusual conjugated fatty acid with industrial value.
Peizhen Yang   +4 more
core   +1 more source

Genotoxicity Assessment of Quinoin, a Ribosome Inactivating Protein from Quinoa Seeds, in the Teleost Danio rerio

open access: yesFrontiers in Bioscience-Landmark
Background: Ribosome inactivating proteins (RIPs) are N-glycosylases found in various plants that are able to specifically and irreversibly inhibit protein translation, thereby leading to cell death. Their cytotoxic properties have attracted attention in
Filomena Mottola   +6 more
doaj   +1 more source

Preparation of an antitumor and antivirus agent: chemical modification of α-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol

open access: yesInternational Journal of Nanomedicine, 2012
Yao Meng,1,2 Shuangfeng Liu,1 Juan Li,3 Yanfa Meng,3 Xiaojun Zhao2,41School of Medical Laboratory Science, Chengdu Medical College, Chengdu, China; 2West China Hospital Laboratory of Nanomedicine and Institute for Nanobiomedical Technology and Membrane ...
Meng Y, Liu S, Li J, Meng Y, Zhao X
doaj  

Comparative study of lectin domains in model species : new insights into evolutionary dynamics [PDF]

open access: yes, 2017
Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses
Dang, Liuyi   +5 more
core   +3 more sources

Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins [PDF]

open access: yes, 2015
Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood.
Diamond, Michael S   +5 more
core   +4 more sources

Home - About - Disclaimer - Privacy