Results 51 to 60 of about 30,415 (253)

Bouganin, an Attractive Weapon for Immunotoxins

Toxins, 2018
Bougainvillea (Bougainvillea spectabilis Willd.) is a plant widely used in folk medicine and many extracts from different tissues of this plant have been employed against several pathologies.
Massimo Bortolotti, Andrea Bolognesi, Letizia Polito   +2 more
doaj   +1 more source

Structure and Activity of a Cytosolic Ribosome-Inactivating Protein from Rice

Toxins, 2019
Ribosome-inactivating proteins (RIPs) are cytotoxic enzymes that inhibit protein translation by depurinating ribosomal RNA. Although most plant RIPs are synthesized with leader sequences that sequester them away from the host ribosomes, several RIPs from
Jeroen De Zaeytijd, Pierre Rougé, Guy Smagghe, Els J.M. Van Damme   +3 more
doaj   +1 more source

Involvement of loops 2 and 3 of alpha-sarcin on its ribotoxic activity [PDF]

, 2015
Ribotoxins are a family of fungal ribosome-inactivating proteins displaying highly specific ribonucleolytic activity against the sarcin/ricin loop (SRL) of the larger rRNA, with a-sarcin as its best-characterized member.
Castaño Rodríguez, Carlos, García Ortega, Lucía, Gavilanes, José G., Lacadena García-Gallo, Javier, Martínez del Pozo, Álvaro, Olombrada Sacristán, Miriam, Oñaderra Sánchez, Mercedes, Partida Hanon, Angélica   +7 more
core   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Alcock F., Allen S., Allen S. C., Argent R. H., Arndt V., Bar-Nun S., Barlowe C., Bazirgan O. A., Bellisola G., Biederer T., Bordallo J., Caldwell S. R., Carroll S. M., Carvalho P., Chaddock J. A., Christianson J. C., Christopher P. Guise, Deeks E. D., Denic V., Di Cola A., Duden R., Elkabetz Y., Endo Y., Gaber R. F., Gauss R., Ghislain M., Gietz R. D., Gillece P., Graham Ladds, Graham T. R., Haynes C. M., Hazes B., Heiligenstein S., Heinemeyer W., Hitt R., J. Michael Lord, Jarosch E., Jarosch E., Kaiser C. A., Kawaguchi S., Kim I., Kim Y., Knop M., Kohler A., Lipson C., Lord J. M., Lynne M. Roberts, Manfred J. Schmitt, Marshall R. S., Mayerhofer P. U., Medicherla B., Metzger M. B., Meusser B., Nakatsukasa K., Nishikawa S. I., Rabinovich E., Robert A. Spooner, Rodighiero C., Rouiller I., Rubin D. M., Sharma N., Shuyu Li, Sikorski R. S., Simpson J. C., Simpson J. C., Spear E. D., Spooner R. A., Spooner R. A., Spooner R. A., Springer S., Stuart C. H. Allen, Taxis C., Thomas Sommer, Tina Schnöder, Vashist S., Vashist S., Vogel J. P., Wesche J., Wilson J. D., Xia Z., Ye Y., Ye Y.   +81 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

LC-HRMS Screening and Identification of Novel Peptide Markers of Ricin Based on Multiple Protease Digestion Strategies

Toxins, 2019
Both ricin and R. communis agglutinin (RCA120), belonging to the type II ribosome-inactivating proteins (RIPs-Ⅱ), are derived from the seeds of the castor bean plant. They share very similar amino acid sequences, but ricin is much more toxic than RCA120.
Long-Hui Liang, Chang-Cai Liu, Bo Chen, Long Yan, Hui-Lan Yu, Yang Yang, Ji-Na Wu, Xiao-Sen Li, Shi-Lei Liu   +8 more
doaj   +1 more source

Inducible antiviral activity and rapid production of the Ribosome-Inactivating Protein I from Phytolacca heterotepala in tobacco

, 2008
We studied the in vitro and in planta antiviral activity of the PhRIP I, a type 1 Ribosome-Inactivating Protein originally purified from leaves of the Phytolacca heterotepala.
ANTIMO DI MARO, AUGUSTO PARENTE, DANIELA ALIOTO, GIANDOMENICO CORRADO, LETIZIA POLITO, MARIAROSARIA SCARPETTA, R. RAO   +6 more
core   +1 more source

Fusidic acid‐dependent ribosomal complexes protect Escherichia coli ribosomes from the action of the type 1 ribosome‐inactivating protein crotin 2

FEBS Letters, 1993
The type 1 ribosome‐inactivating protein crotin 2 depurinated Escherichia coli ribosomes which, upon treatment of the isolated rRNA with acid aniline, released a fragment of around 240 nucleotides whose 5'‐end sequence was 5'‐GAGGACCGGAGUGGAC‐3'. The formation of fusidic acid‐dependent ribosomal complexes completely prevented release of the fragment ...
Iglesias, Rosario, Escarmis, Cristina, Alegre, Carlos, Ferreras, J.Miguel, Girbés, Tomás   +4 more
openaire   +3 more sources

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source