Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme. [PDF]
, 2016 Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome ...
Fujimori, Danica Galonić +3 more
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Synthetic biology—putting engineering into biology [PDF]
, 2006 Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
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Two complementary approaches for intracellular delivery of exogenous enzymes. [PDF]
, 2015 Intracellular delivery of biologically active proteins remains a formidable challenge in biomedical research. Here we show that biomedically relevant enzymes can be delivered into cells using a new DNA transfection reagent, lipofectamine 3000, allowing ...
Abbas, S.A. +9 more
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MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
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Ricinus Agglutinin Induced Autophagy in Glioblastoma Cells [PDF]
, 2015 Ricinus agglutinin (RA) is a heterodimer consisting of two chains known as chain A and chain B respectively. The molecular weight of RA is 120 kD. RA is highly toxic to normal cells due to its ability to bind to the carbohydrate moieties present on the ...
Sahoo, puja
core
Mining the bitter melon (momordica charantia l.) seed transcriptome by 454 analysis of non-normalized and normalized cDNA populations for conjugated fatty acid metabolism-related genes [PDF]
, 2010 Background Seeds of Momordica charantia (bitter melon) produce high levels of eleostearic acid, an unusual conjugated fatty acid with industrial value.
Peizhen Yang +4 more
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Frontiers in Bioscience-LandmarkBackground: Ribosome inactivating proteins (RIPs) are N-glycosylases found in various plants that are able to specifically and irreversibly inhibit protein translation, thereby leading to cell death. Their cytotoxic properties have attracted attention in
Filomena Mottola +6 more
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International Journal of Nanomedicine, 2012 Yao Meng,1,2 Shuangfeng Liu,1 Juan Li,3 Yanfa Meng,3 Xiaojun Zhao2,41School of Medical Laboratory Science, Chengdu Medical College, Chengdu, China; 2West China Hospital Laboratory of Nanomedicine and Institute for Nanobiomedical Technology and Membrane ...
Meng Y, Liu S, Li J, Meng Y, Zhao X
doaj
Comparative study of lectin domains in model species : new insights into evolutionary dynamics [PDF]
, 2017 Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses
Dang, Liuyi +5 more
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Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins [PDF]
, 2015 Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood.
Diamond, Michael S +5 more
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