Results 71 to 80 of about 30,415 (253)

The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]

, 2013
The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Afshar, Allen, Argent, Bays, Bellisola, Blum, Braun, Brodsky, Carvalho, Cascio, Craiu, David M. Roberts, Deeks, Elkabetz, Endo, Fiani, Fleming, Fu, Gallastegui, Giodini, Groll, Hartley, Hazes, Heiligenstein, Heinemeyer, Hendil, Holmberg, Hudson, Husnjak, J. Michael Lord, Jarosch, Jin, Jonathan P. Cook, Kohler, Lam, Li, Li, Lipson, Lundgren, Lynne M. Roberts, May, Mayerhofer, Nishi Vasisht, Paola Pietroni, Rabinovich, Rasmus Hartmann-Petersen, Redmann, Robert A. Spooner, Rubin, Sandvig, Schreiner, Sokolowska, Spooner, Spooner, Spooner, Spooner, Strickland, Surjit, Unno, van Nocker, Wesche, Ye   +61 more
core   +2 more sources

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Ebulin 1, a nontoxic novel type 2 ribosome-inactivating protein from Sambucus ebulus L. leaves.

Journal of Biological Chemistry, 1993
A novel type 2 ribosome-inactivating protein (RIP) that we named ebulin 1 has been isolated from leaves of Sambucus ebulus L. (Caprifoliaceae). In vitro ebulin 1 strongly inhibited protein synthesis by rabbit reticulocyte lysates, rat brain, and rat liver cell-free systems but did not affect in vitro plant nor bacterial protein synthesis.
T, Girbés, L, Citores, R, Iglesias, J M, Ferreras, R, Muñoz, M A, Rojo, F J, Arias, J R, García, E, Méndez, M, Calonge   +9 more
openaire   +2 more sources

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Lectinas vegetales: utilización en histoquímica y terapia antitumoral [PDF]

, 2016
Numerosas plantas expresan en su composición una o más lectinas o bien proteínas con un dominio lectina, permitiendo a éstas seleccionar y unirse a determinadas estructuras.
Velasco Martín, Felipe
core  

MTOR cross-talk in cancer and potential for combination therapy [PDF]

, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C., Bria, E., Ciuffreda, L., Cognetti, F., Conciatori, F., Falcone, I., Milella, M, Pilotto, S.   +7 more
core   +3 more sources

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Avoiding chromosome pathology when replication forks collide [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG, Nieduszynski, CA, Stockum, A, Upton, AL   +3 more
core   +1 more source

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, EarlyView.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity [PDF]

, 2004
We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of chromosomal DNA, respectively. Colicin E9 strongly induced the
Hinton, Jay C. D., James, Richard, Kleanthous, Colin, Moore, Geoffrey R., Rolfe, Matthew, Thompson, Arthur, WALKER, DANIEL   +6 more
core   +2 more sources