Results 71 to 80 of about 25,229 (271)

Kirkiin: A New Toxic Type 2 Ribosome-Inactivating Protein from the Caudex of Adenia kirkii

Toxins, 2021
Ribosome-inactivating proteins (RIPs) are plant toxins that irreversibly damage ribosomes and other substrates, thus causing cell death. RIPs are classified in type 1 RIPs, single-chain enzymatic proteins, and type 2 RIPs, consisting of active A chains ...
Massimo Bortolotti, Stefania Maiello, José M. Ferreras, Rosario Iglesias, Letizia Polito, Andrea Bolognesi   +5 more
doaj   +1 more source

Characterization of a new toxin from the entomopathogenic fungus Metarhizium anisopliae: the ribotoxin anisoplin [PDF]

, 2016
Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest.
Budia, Flor, García Ortega, Lucía, Gavilanes, José, Martínez del Pozo, Álvaro, Medina, Pilar, Olombrada, Miriam   +5 more
core   +2 more sources

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

Arabidopsis Bax Inhibitor-1 inhibits cell death induced by pokeweed antiviral protein in Saccharomyces cerevisae

Microbial Cell, 2015
Apoptosis is an active form of programmed cell death (PCD) that plays critical roles in the development, differentiation and resistance to pathogens in multicellular organisms. Ribosome inactivating proteins (RIPs) are able to induce apoptotic cell death
Birsen Çakır, Nilgun E. Tumer
doaj   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Alcock F., Allen S., Allen S. C., Argent R. H., Arndt V., Bar-Nun S., Barlowe C., Bazirgan O. A., Bellisola G., Biederer T., Bordallo J., Caldwell S. R., Carroll S. M., Carvalho P., Chaddock J. A., Christianson J. C., Christopher P. Guise, Deeks E. D., Denic V., Di Cola A., Duden R., Elkabetz Y., Endo Y., Gaber R. F., Gauss R., Ghislain M., Gietz R. D., Gillece P., Graham Ladds, Graham T. R., Haynes C. M., Hazes B., Heiligenstein S., Heinemeyer W., Hitt R., J. Michael Lord, Jarosch E., Jarosch E., Kaiser C. A., Kawaguchi S., Kim I., Kim Y., Knop M., Kohler A., Lipson C., Lord J. M., Lynne M. Roberts, Manfred J. Schmitt, Marshall R. S., Mayerhofer P. U., Medicherla B., Metzger M. B., Meusser B., Nakatsukasa K., Nishikawa S. I., Rabinovich E., Robert A. Spooner, Rodighiero C., Rouiller I., Rubin D. M., Sharma N., Shuyu Li, Sikorski R. S., Simpson J. C., Simpson J. C., Spear E. D., Spooner R. A., Spooner R. A., Spooner R. A., Springer S., Stuart C. H. Allen, Taxis C., Thomas Sommer, Tina Schnöder, Vashist S., Vashist S., Vogel J. P., Wesche J., Wilson J. D., Xia Z., Ye Y., Ye Y.   +81 more
core   +2 more sources

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, EarlyView.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Comparative study of lectin domains in model species : new insights into evolutionary dynamics [PDF]

, 2017
Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses
Dang, Liuyi, De Schutter, Kristof, Eggermont, Lore, Tsaneva, Mariya Tsankova, Van Damme, Els, Van Holle, Sofie   +5 more
core   +3 more sources