Results 191 to 200 of about 43,196 (233)

Rp3: Ribosome profiling-assisted proteogenomics improves coverage and confidence during microprotein discovery. [PDF]

Nat Commun
Vieira de Souza E, L Bookout A, Barnes CA, Miller B, Machado P, Basso LA, Bizarro CV, Saghatelian A.   +7 more
europepmc   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Identification and functional validation of a novel disease‐causing variant in the noncoding region of NYX

Acta Ophthalmologica, EarlyView.
Abstract Purpose Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders, with ~30% of cases remaining genetically unsolved. Complete congenital stationary night blindness (cCSNB) is a subtype of IRD, usually associated with reduced visual acuity, nystagmus and high myopia.
Spanic Filip, Michiels Christelle, Navarro Julien, Antonio Aline, Condroyer Christel, Andrieu Camille, Gipsy Billy, Berthémy‐Pellet Sylvie, Gallice Mathilde, Audo Isabelle, Zeitz Christina   +10 more
wiley   +1 more source

Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

British Journal of Haematology, EarlyView.
We show how the loss of activity of the translation initiation factor EIF5A2—either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post‐translational modification—induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.
Eva Crespo‐García, Carlos Quero‐Dotor, Aleix Noguera‐Castells, Laia Sancho‐Vila, Laura Martinez‐Verbo, Manel Esteller   +5 more
wiley   +1 more source

Widespread stable noncanonical peptides identified by integrated analyses of ribosome profiling and ORF features. [PDF]

Nat Commun
Yang H, Li Q, Stroup EK, Wang S, Ji Z.
europepmc   +1 more source

A rapid protocol for ribosome profiling of low input samples

, 2022
Meindl A, Romberger M, Lehmann G, Eichner N, Kleemann L, Wu J, Danner J, Boesl M, Mesitov M, Meister G, König J, Leidel S, Medenbach J.   +12 more
europepmc   +1 more source

Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

Cell Proliferation, EarlyView.
IL10_ApoEVs, generated during IL‐10‐induced fibroblast apoptosis, reprogram fibroblast metabolism and inhibit fibrosis to promote scarless skin healing. By enhancing mitochondrial OXPHOS, suppressing glycolysis, and downregulating Hedgehog signaling, IL10_ApoEVs shift collagen deposition toward regenerative type III collagen, offering a novel strategy ...
Yang Zou, Jinglun Zhang, Wenxuan Mao, Shuting Jiang, Cheng Xu, Jiayi Meng, Heng Dong, Yongbin Mou   +7 more
wiley   +1 more source

Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation. [PDF]

iScience
Barlit H, Romero AM, Gülhan A, Patnaik PK, Tyshkovskiy A, Martínez-Pastor MT, Gladyshev VN, Puig S, Labunskyy VM.   +8 more
europepmc   +1 more source

p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway

Cell Proliferation, EarlyView.
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao, Hongyan Yuan, Di Wang, Meng Li, Bo Xie, Xuqiang Zou, Mingjie Lu, Ye Qiu, Jinlin Song   +8 more
wiley   +1 more source

choros: correction of sequence-based biases for accurate quantification of ribosome profiling data

, 2023
Mok A, Tunney R, Benegas G, Wallace EWJ, Lareau LF.   +4 more
europepmc   +1 more source