Results 191 to 200 of about 188,278 (356)

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Depurination of sarcin/ricin loop 25S rRNA is signaled through the small ribosomal subunit during translation. [PDF]

RNA
Prashar T, Hudak KA.
europepmc   +1 more source

The Cryo-EM Structure of the Ribosome Bound to BipA [PDF]

, 2014
Danny Nam Ho, Ala M. Shaqra, Wen Li, Megan A. deLivron, Gil Dionne, Ning Gao, Victoria Robinson, Joachim Frank   +7 more
openalex   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Visualizing the translation landscape in human cells at high resolution. [PDF]

Nat Commun
Zheng W, Zhang Y, Wang J, Wang S, Chai P, Bailey EJ, Zhu C, Guo W, Devarkar SC, Wu S, Lin J, Zhang K, Liu J, Lomakin IB, Xiong Y.   +14 more
europepmc   +1 more source

Total reconstitution of E. coli 50S ribosomes [PDF]

, 1975
A Correspondent
openalex   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Biosynthesis Of Glyoxysomal Enzymes In Neurospora Crassa [PDF]

, 1982
Flavell R. B., Frevert J., Fritz Miller, Gerhardt B., Herbert Desel, Johanson R. A., Kanarek L., Kindl, KOLLER W., Michael Janes, Mukkerjee A., Novikoff A. B., Richard Zimmermann, Riezman H., Srere P. A., Theimer R. R., Thorne C. J. R., Walter Neupert   +17 more
core   +1 more source

NIR Light‐Driven Photocatalytic Antibacterial Hydrogels for Synergistic MRSA Biofilm Eradication and Wound Regeneration

Advanced Science, EarlyView.
The nanohybrid hydrogel (Fe‐BOS@C/H Gel) is composed of Fe‐Bi2O2‐XS (Fe‐BOS) photocatalysts and CS‐ADH/OHA (C/H) hydrogel. Fe‐BOS photocatalysts achieve near‐infrared (NIR) light‐driven antibacterial photocatalytic/mild photothermal therapy (APCT/MPTT), effectively eliminating methicillin‐resistant Staphylococcus aureus (MRSA) biofilms. The degradation
Dong Mo, Yujia Wei, Meng Pan, Wen Chen, Yun Yang, Kang Li, Xicheng Li, Jianan Li, Qingya Liu, Hanzi Deng, Mei Zhu, Zhenpeng Zhang, Zhaolin Xiao, Zhiyong Qian   +13 more
wiley   +1 more source

Structure of Ribosome-Inactivating Protein from <i>Mirabilis jalapa</i> and Its L12-Stalk-Dependent Inhibition of <i>Escherichia coli</i> Ribosome. [PDF]

Toxins (Basel)
Nishida N, Ninomiya Y, Yoshida T, Tanzawa T, Maki Y, Yoshida H, Tsuge H, Habuka N.   +7 more
europepmc   +1 more source