Results 261 to 270 of about 188,278 (356)

Ribosomal RNA operon copy number: A trait‐informed framework to close the microbial cultivation gap

iMetaOmics, EarlyView.
The vast majority of microbes remain uncultured, constraining functional validation and limiting microbiome‐based applications. We show that ribosomal RNA operon (rrn) copy number—a stable, phylogenetically conserved genomic trait—is strongly correlated with cultivation outcomes across ecosystems.
Yuxiao Huang, Qingliu Wu, Chang Liu, Pugang Yu, Hao Li, Shengyue Tang, Fusuo Zhang, Shuangjiang Liu, Bin Ni   +8 more
wiley   +1 more source

A Duality of Function: An Integrative Model of RACK1 as a Switch Between Translational and Signaling Hubs. [PDF]

Int J Mol Sci
Kolosov P, Biziaev N, Alkalaeva E.
europepmc   +1 more source

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA. [PDF]

Mol Cell
Lentzsch AM, Fan Z, Irshad IU, O'Brien EP, Sharma AK, Green R, Shan SO.   +6 more
europepmc   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Near-cognate tRNAs enhance tRNA rejection and prime the ribosome for rapid subsequent tRNA testing. [PDF]

Biophys J
Fritsch C, Bhattacharya A, Ng MY, Li H, Nelson PC, Cooperman BS, Goldman YE.   +6 more
europepmc   +1 more source

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, EarlyView.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

ZAKα is a sensor of mRNA stasis at the ribosomal exit channel

Vind AC, Martínez JF, Wu Z, Bugai A, Mordente K, Chen Q, Rasmussen M, He D, Svejstrup JQ, Jensen TH, Blasius M, Bekker-Jensen S.   +11 more
europepmc   +1 more source

Remodeling of Germ Cell mRNPs for Translational Control. [PDF]

Biology (Basel)
Keiper BD, Huggins HP.
europepmc   +1 more source