Results 271 to 280 of about 105,196 (322)

Fiber Type‐Specific Proteomic Alterations in R349P Desminopathy Mice

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Desminopathies are a group of rare human myopathies and cardiomyopathies caused by pathogenic variants of the desmin gene. Here, we analyzed the effects of the R349P mutant desmin on the proteomic profiles of individual fiber types of murine skeletal muscle.
Britta Eggers, Karin Schork, Michael Turewicz, Katalin Barkovits, Martin Eisenacher, Rolf Schröder, Christoph Stephan Clemen, Katrin Marcus   +7 more
wiley   +1 more source

Progress in Aptamer Research and Future Applications

ChemistryOpen, EarlyView.
This paper mainly describes the screening method of aptamer, the screening difficulties and improvement methods of small molecule aptamer, and the application and treatment of aptamer. It explores the latest progress and application of aptamers, and summarises them, thus indicating some problems that still exist in this field.
Song Liu, Xiaolu Li, Huyang Gao, Jing Chen, Hongfeng Jiang   +4 more
wiley   +1 more source

The coordinated action of UFMylation and ribosome-associated quality control pathway clears arrested nascent chains at the endoplasmic reticulum

Mihailovic M, Anisimova AS, Erte B, Zhan N, Styliara I, Dagdas Y, Karagöz GE.   +6 more
europepmc   +1 more source

Protein translation can fluidize bacterial cytoplasm. [PDF]

PNAS Nexus
Bera P, Wasim A, Bakshi S, Mondal J.
europepmc   +1 more source

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes. [PDF]

Science
Zhu X, Cruz VE, Zhang H, Erzberger JP, Mendell JT.   +4 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis. [PDF]

Cell Rep
Khalatyan N, Cornish D, Ferrell AJ, Savas JN, Shen PS, Hultquist JF, Walsh D.   +6 more
europepmc   +1 more source

Target gene selection for sprayable dsRNA‐based biopesticide against Tetranychus urticae Koch (Acari: Tetranychidae)

Pest Management Science, EarlyView.
Silencing Prosbeta‐5 and Prosbeta‐1 resulted in high mortality in Tetranychus urticae, identifying them as potential target genes for double‐stranded RNA‐based biopesticides using spray‐induced gene silencing (SIGS). Abstract BACKGROUND Because of the excessive use of synthetic chemicals, the two‐spotted spider mite, Tetranychus urticae Koch, a highly ...
Yifei Wang, Yuanpeng Duan, Meibin Liu, Meifeng Ren, Yue Gao, Zhongfang Liu, Pengjiu Zhang, Lifei He, Renjun Fan, Xuguo Zhou, Jing Yang   +10 more
wiley   +1 more source

NAC regulates metabolism and cell fate in intestinal stem cells. [PDF]

Sci Adv
Ramalho S, Alkan F, Prekovic S, Jastrzebski K, Barberà EP, Hoekman L, Altelaar M, de Heus C, Liv N, Rodríguez-Colman MJ, Yilmaz M, van der Kammen R, Fedry J, de Gooijer MC, Suijkerbuijk SJE, Faller WJ, Silva J.   +16 more
europepmc   +1 more source

Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐tRNA synthetase

Pest Management Science, EarlyView.
The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
David Bernier, David M Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Luke Churchman, Uwe Döller, Tyler Fahrenhorst‐Jones, Jörg Freigang, Elmar Gatzweiler, Claudia Hartfiel, Caroline Hilmi, Yoann Huet, Bernd Laber, Gudrun Lange, Stephanie Lee, Virginie Lempereur, Marc Mosrin, Thomas Müller, China M Payne, Olaf Peters, Luka Posa, Shaun Rees, Anna M Reingruber, Jullien Rey, Jörg Tiebes, Karen Tilmant, Jens Frackenpohl   +26 more
wiley   +1 more source