Results 291 to 300 of about 184,288 (339)

Integrative Multiparametric Analysis of Circulating Cell‐Free Nucleic Acids of Plasma in Healthy Individuals During Aging

Aging Cell, EarlyView.
We performed the first integrative multiparametric analysis of plasma circulating cell‐free nucleic acids, including nuclear and mitochondrial DNA, as well as ribosomal, messenger, and micro‐RNAs, in a cohort of 139 healthy individuals. We focused on quantity, integrity, and DNA methylation using assays targeting highly repetitive DNA and highly ...
Nicolas P. Tessier, Lise M. Hardy, Florence Mauger, Antoine Daunay, Christian Daviaud, Ilef Hchaichi, Caroline Horgues, Mourad Sahbatou, Hélène Le Buanec, Jean‐François Deleuze, Alexandre How‐Kit   +10 more
wiley   +1 more source

Built differently or defective: can RNA exosomopathies cause ribosome heterogeneity? [PDF]

Philos Trans R Soc Lond B Biol Sci
Bressman ZJ, Corbett AH, Ghalei H.
europepmc   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

rRNA expression kinetics during the chlamydial developmental cycle

Microbiology Spectrum
Yuxuan Wang, Joseph D. Fondell, Guangming Zhong, Huizhou Fan   +3 more
doaj   +1 more source

Ribosomes: from conserved origin to functional/medical mobility and heterogeneity. [PDF]

Philos Trans R Soc Lond B Biol Sci
Rivalta A, Hiregange DG, Bose T, Rajan KS, Yonath A, Zimmerman E, Waghalter M, Fridkin G, Martinez-Roman I, Rosenfield L, Fedorenko A, Bashan A, Yonath H.   +12 more
europepmc   +1 more source

Altered Relaxation and Mitochondria‐Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise

Aging Cell, EarlyView.
Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise. ABSTRACT Sarcopenia, or age‐related muscle dysfunction, contributes to morbidity and mortality. Besides decreases in muscle force, sarcopenia is associated with atrophy and fast‐to‐slow fiber type switching, which is typically secondary to
Ryan J. Allen, Ana Kronemberger, Qian Shi, R. Marshall Pope, Elizabeth Cuadra‐Muñoz, Wangkuk Son, Long‐Sheng Song, Ethan J. Anderson, Renata O. Pereira, Vitor A. Lira   +9 more
wiley   +1 more source

Lipid Droplets are active translation depots that respond to infection

Jha RM, Menon D, Nahak A, Kumar A, Choudhary V, Gandotra S.   +5 more
europepmc   +1 more source

Pelota: A double-edged sword in virus infection. [PDF]

PLoS Pathog
Li X, Zhou X, Li F.
europepmc   +1 more source

Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis

Aging Cell, EarlyView.
In aging or fibrotic fibroblasts, NUDT21 is downregulated, leading to alternative polyadenylation/3′ UTR shortening of STAT3 pathway genes, enhancing their protein expression and promoting STAT3 phosphorylation. Activated STAT3 signaling subsequently drives the expression and release of senescence‐associated secretory phenotype (SASP) factors, thereby ...
Jingjing Huang, Maria Jose Gacha‐Garay, Yu Wang, Scott D. Collum, Rene A. Girard, Hydia Puente, Seung‐Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J. Wagner, Hari KrishnaYalamanchili, Harry Karmouty‐Quintana, Zheng Chen, Tingting Mills   +14 more
wiley   +1 more source