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Current Opinion in Chemical Biology, 2022
All cells must manage deficiency, sufficiency, and excess of essential metal ions. Although iron has been one of most important metals in biology for billions of years, the mechanisms by which bacteria cope with high intracellular iron concentrations are only recently coming into focus. Recent work has suggested that an RNA riboswitch (czcD or "NiCo"),
Jiansong, Xu, Joseph A, Cotruvo
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All cells must manage deficiency, sufficiency, and excess of essential metal ions. Although iron has been one of most important metals in biology for billions of years, the mechanisms by which bacteria cope with high intracellular iron concentrations are only recently coming into focus. Recent work has suggested that an RNA riboswitch (czcD or "NiCo"),
Jiansong, Xu, Joseph A, Cotruvo
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Combinatorial Chemistry & High Throughput Screening, 2019
Background: Riboswitches are cis-acting, non-coding RNA elements found in the 5’UTR of bacterial mRNA and 3’ UTR of eukaryotic mRNA, that fold in a complex manner to act as receptors for specific metabolites hence altering their conformation in response to the change in concentrations of a ligand or metabolite. Riboswitches function as gene regulators
Angela, Gupta, D, Swati
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Background: Riboswitches are cis-acting, non-coding RNA elements found in the 5’UTR of bacterial mRNA and 3’ UTR of eukaryotic mRNA, that fold in a complex manner to act as receptors for specific metabolites hence altering their conformation in response to the change in concentrations of a ligand or metabolite. Riboswitches function as gene regulators
Angela, Gupta, D, Swati
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Science, 2008
Using simple biochemical tricks, metabolite-binding riboswitches take on gene control functions that have long been thought to be the work of protein factors. Although modern riboswitches might be the last holdouts of primitive genetic elements, some are capable of sensory and regulatory feats that are competitive with their protein counterparts.
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Using simple biochemical tricks, metabolite-binding riboswitches take on gene control functions that have long been thought to be the work of protein factors. Although modern riboswitches might be the last holdouts of primitive genetic elements, some are capable of sensory and regulatory feats that are competitive with their protein counterparts.
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Riboswitches: natural SELEXion
Cellular and Molecular Life Sciences, 2005Advances in our knowledge of the structure and chemistry of RNA have been harnessed in the process known as SELEX to develop artificial RNA-based molecules that can act as enzymes and ligand binders performing a wide variety of functions. The discovery of riboswitches, natural RNA aptamers involved in genetic regulation, offers a basis of comparison ...
S D, Gilbert, R T, Batey
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Science Signaling, 2010
A metabolite-sensing riboswitch regulates the splicing of a “selfish” group I self-splicing ribozyme.
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A metabolite-sensing riboswitch regulates the splicing of a “selfish” group I self-splicing ribozyme.
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Science, 2012
A fluoride-sensing riboswitch regulates the expression of putative fluoride channels in prokaryotes.
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A fluoride-sensing riboswitch regulates the expression of putative fluoride channels in prokaryotes.
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Scientific American, 2007
A mystery surrounding the way bacteria manage their vitamins piqued our interest in the fall of 2000. Together with growing evidence in support of a tantalizing theory about the earliest life on earth and our own efforts to build switches from biological molecules, the bacterial conundrum set our laboratory group at Yale University in search of an ...
Jeffrey E, Barrick, Ronald R, Breaker
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A mystery surrounding the way bacteria manage their vitamins piqued our interest in the fall of 2000. Together with growing evidence in support of a tantalizing theory about the earliest life on earth and our own efforts to build switches from biological molecules, the bacterial conundrum set our laboratory group at Yale University in search of an ...
Jeffrey E, Barrick, Ronald R, Breaker
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Gene regulation by riboswitches
Nature Reviews Molecular Cell Biology, 2004Riboswitches are complex folded RNA domains that serve as receptors for specific metabolites. These domains are found in the non-coding portions of various mRNAs, where they control gene expression by harnessing allosteric structural changes that are brought about by metabolite binding.
Maumita, Mandal, Ronald R, Breaker
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Guanidine throws the riboswitch
Science Signaling, 2017A bacterial riboswitch responds to endogenously produced guanidine.
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Design of Transcription Regulating Riboswitches
2015In this chapter, we review both computational and experimental aspects of de novo RNA sequence design. We give an overview of currently available design software and their limitations, and discuss the necessary setup to experimentally validate proper function in vitro and in vivo.
Findeiß, Sven +3 more
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