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Preparation and Crystallization of Riboswitches
2016Recent studies have revealed that the majority of biological processes are controlled by noncoding RNAs. Among many classes of noncoding RNAs, metabolite-sensing segments of mRNAs called riboswitches are unique. Discovered over a decade ago in all three kingdoms of life, riboswitches specifically and directly interact with various metabolites and ...
Alla, Peselis +2 more
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Guanidine throws the riboswitch
Science Signaling, 2017A bacterial riboswitch responds to endogenously produced guanidine.
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Computational Prediction of Riboswitches
2015Riboswitches present a ubiquitous genetic regulatory mechanism for prokaryotes and have been found in HIV1, fungi, plants, and even H. sapiens. We present an overview of approaches to predict riboswitch aptamers and, more generally, RNA conformational switches.
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Design of Transcription Regulating Riboswitches
2015In this chapter, we review both computational and experimental aspects of de novo RNA sequence design. We give an overview of currently available design software and their limitations, and discuss the necessary setup to experimentally validate proper function in vitro and in vivo.
Findeiß, Sven +3 more
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Thermodynamic and Kinetic Folding of Riboswitches
2015Riboswitches are structured RNA regulatory elements located in the 5'-UTRs of mRNAs. Ligand-binding induces a structural rearrangement in these RNA elements, effecting events in downstream located coding sequences. Since they do not require proteins for their functions, they are ideally suited for computational analysis using the toolbox of RNA ...
Badelt, Stefan +3 more
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Science Signaling, 2008
In bacteria, the second messenger cyclic di-guanosine monophosphate (di-GMP) regulates a wide range of genes and affects diverse physiological (and disease-causing) processes. It has been suggested that cyclic di-GMP may modulate transcription and translation via specific cyclic di-GMP riboswitches.
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In bacteria, the second messenger cyclic di-guanosine monophosphate (di-GMP) regulates a wide range of genes and affects diverse physiological (and disease-causing) processes. It has been suggested that cyclic di-GMP may modulate transcription and translation via specific cyclic di-GMP riboswitches.
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Science's STKE, 2004
RNA gene control elements, or "riboswitches," can regulate gene expression in ways that were once thought to be the domain of proteins. Mandal et al. (see the Perspective by Famulok) now show that adjacent RNA motifs cooperatively bind two molecules of glycine in Bacillus subtilis and turn on
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RNA gene control elements, or "riboswitches," can regulate gene expression in ways that were once thought to be the domain of proteins. Mandal et al. (see the Perspective by Famulok) now show that adjacent RNA motifs cooperatively bind two molecules of glycine in Bacillus subtilis and turn on
openaire +1 more source
High content design of riboswitch biosensors: All-around rational module-by-module design
Biosensors and Bioelectronics, 2023Longjiao Zhu, Huashuo Chu, Wentao Xu
exaly
Advances in riboswitch‐based biosensor as food samples detection tool
Comprehensive Reviews in Food Science and Food Safety, 2023Xiaoze Dong +2 more
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