Results 251 to 260 of about 28,198 (287)
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The Novel Chemical Mechanism of the Twister Ribozyme.
Journal of the American Chemical Society, 2016We describe the multifactorial origins of catalysis by the twister ribozyme. We provide evidence that the adenine immediately 3' to the scissile phosphate (A1) acts as a general acid.
T. J. Wilson +4 more
semanticscholar +1 more source
Current Opinion in Biotechnology, 1992
RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation.
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RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation.
openaire +2 more sources
2015
Ribozymes are structured RNA molecules that act as catalysts in different biological reactions. From simple genome cleaving activities in satellite RNAs to more complex functions in cellular protein synthesis and gene regulation, ribozymes play important roles in all forms of life.
Anne Gatignol, Robert J. Scarborough
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Ribozymes are structured RNA molecules that act as catalysts in different biological reactions. From simple genome cleaving activities in satellite RNAs to more complex functions in cellular protein synthesis and gene regulation, ribozymes play important roles in all forms of life.
Anne Gatignol, Robert J. Scarborough
openaire +3 more sources
Molecular and Cellular Neuroscience, 1998
The selective inactivation of genes, in a tissue-specific or temporally controlled manner, is now an important requirement for the analysis of nervous system development and function. Hammerhead ribozymes--catalytic RNA enzymes that specifically bind to and then cleave target RNAs--may provide a way to meet this requirement, particularly for organisms ...
Jack Jiagang Zhao, Greg Lemke
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The selective inactivation of genes, in a tissue-specific or temporally controlled manner, is now an important requirement for the analysis of nervous system development and function. Hammerhead ribozymes--catalytic RNA enzymes that specifically bind to and then cleave target RNAs--may provide a way to meet this requirement, particularly for organisms ...
Jack Jiagang Zhao, Greg Lemke
openaire +3 more sources
Biopolymers, 1998
In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions.
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In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions.
openaire +2 more sources
Ribozyme Structures and Mechanisms
Annual Review of Biophysics and Biomolecular Structure, 2000▪ Abstract The past few years have seen exciting advances in understanding the structure and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed insight into the folds of RNA molecules. Models of other biologically important RNAs have been constructed based on structural, phylogenetic, and biochemical data ...
Elizabeth A. Doherty, Jennifer A. Doudna
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ACS Synthetic Biology, 2015
Systems for conditional gene expression are powerful tools in basic research as well as in biotechnology. For future applications, it is of great importance to engineer orthogonal genetic switches that function reliably in diverse contexts.
Benedikt Klauser +3 more
semanticscholar +1 more source
Systems for conditional gene expression are powerful tools in basic research as well as in biotechnology. For future applications, it is of great importance to engineer orthogonal genetic switches that function reliably in diverse contexts.
Benedikt Klauser +3 more
semanticscholar +1 more source
Science, 1999
Ribozymes are RNA molecules that behave like enzymes, cleaving other RNA transcripts into pieces. They have potential therapeutic value because they can be designed to chew up viral RNAs or to repair damaged mRNA transcripts. However, getting the ribozyme to the correct part of the cell where the target RNA resides is a challenge.
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Ribozymes are RNA molecules that behave like enzymes, cleaving other RNA transcripts into pieces. They have potential therapeutic value because they can be designed to chew up viral RNAs or to repair damaged mRNA transcripts. However, getting the ribozyme to the correct part of the cell where the target RNA resides is a challenge.
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Biopolymers, 2003
AbstractThe hairpin ribozyme is a naturally occurring RNA that catalyzes sequence‐specific cleavage and ligation of RNA. It has been the subject of extensive biochemical and structural studies, perhaps the most detailed for any catalytic RNA to date. Comparison of the structures of its constituent domains free and fully assembled demonstrates that the ...
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AbstractThe hairpin ribozyme is a naturally occurring RNA that catalyzes sequence‐specific cleavage and ligation of RNA. It has been the subject of extensive biochemical and structural studies, perhaps the most detailed for any catalytic RNA to date. Comparison of the structures of its constituent domains free and fully assembled demonstrates that the ...
openaire +2 more sources
Journal of Physical Chemistry B, 2015
X-ray crystallography can provide important insights into the structure of RNA enzymes (ribozymes). However, the details of a ribozyme's active site architecture are often altered by the inactivating chemical modifications necessary to inhibit self ...
V. Mlýnský +7 more
semanticscholar +1 more source
X-ray crystallography can provide important insights into the structure of RNA enzymes (ribozymes). However, the details of a ribozyme's active site architecture are often altered by the inactivating chemical modifications necessary to inhibit self ...
V. Mlýnský +7 more
semanticscholar +1 more source