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Practical Ribozymes: Making ribozymes work in cells
Current Biology, 1994Ways are being found to increase the efficacy of ribozymes in cells, offering hope that they may soon begin to fulfill their promise as new reagents for inactivating specific RNAs in cells.
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Thermodynamic Dissection of the Substrate−Ribozyme Interaction in the Hammerhead Ribozyme
Biochemistry, 1998The free energy of substrate binding to the hammerhead ribozyme was compared for 10 different hammerheads that differed in the length and sequence of their substrate recognition helices. These hammerheads were selected because neither ribozyme nor substrate oligonucleotide formed detectable alternate secondary structures.
Tracy K. Stage-Zimmermann +3 more
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Hovlinc is a recently evolved class of ribozyme found in human lncRNA
Nature Chemical Biology, 2021Yue-Qin Chen +6 more
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The Ribosome Functions as a Ribozyme
ChemBioChem, 2001One of the most exciting developments in biological chemistry in the last two decades has been the discovery that RNA can catalyse chemical reactions. This is no longer the sole preserve of protein-based enzymes, and raises the intriguing possibility that in the early appearance of life on this planet it may have passed through a phase in which RNA ...
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2006
The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants.
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The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants.
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Therapeutic applications of ribozymes
Pharmacology & Therapeutics, 1995The demonstration that RNA can be cleaved by cis or trans ribozymes (catalytic RNAs, RNA enzymes) has potentially important therapeutic implications. Since their discovery in the 1980s, the biochemistry and conserved sequences of ribozymes have been well characterized.
Mohammed Kashani-Sabet +4 more
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Molecular Medicine Today, 1998
Abstract Ribozyme-mediated trans -splicing of a trinucleotide repeat Phylactou, L.A., Darrah, C. and Wood, M.J.A. (1998) Nat. Genet.
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Abstract Ribozyme-mediated trans -splicing of a trinucleotide repeat Phylactou, L.A., Darrah, C. and Wood, M.J.A. (1998) Nat. Genet.
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Ribozymes and Their Medical Implications
JAMA: The Journal of the American Medical Association, 1988Certain RNA molecules can mediate their own cleavage or splicing or act as enzymes to promote reactions on substrate RNA molecules. Thus, RNA is not restricted to being a passive carrier of genetic information but can have an active role in directing cellular biochemistry.
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