Results 261 to 270 of about 43,119 (293)
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Biopolymers, 1998
In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions.
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In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions.
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ACS Synthetic Biology, 2015
Systems for conditional gene expression are powerful tools in basic research as well as in biotechnology. For future applications, it is of great importance to engineer orthogonal genetic switches that function reliably in diverse contexts.
Benedikt Klauser +3 more
semanticscholar +1 more source
Systems for conditional gene expression are powerful tools in basic research as well as in biotechnology. For future applications, it is of great importance to engineer orthogonal genetic switches that function reliably in diverse contexts.
Benedikt Klauser +3 more
semanticscholar +1 more source
Science, 1999
Ribozymes are RNA molecules that behave like enzymes, cleaving other RNA transcripts into pieces. They have potential therapeutic value because they can be designed to chew up viral RNAs or to repair damaged mRNA transcripts. However, getting the ribozyme to the correct part of the cell where the target RNA resides is a challenge.
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Ribozymes are RNA molecules that behave like enzymes, cleaving other RNA transcripts into pieces. They have potential therapeutic value because they can be designed to chew up viral RNAs or to repair damaged mRNA transcripts. However, getting the ribozyme to the correct part of the cell where the target RNA resides is a challenge.
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Biopolymers, 2003
AbstractThe hairpin ribozyme is a naturally occurring RNA that catalyzes sequence‐specific cleavage and ligation of RNA. It has been the subject of extensive biochemical and structural studies, perhaps the most detailed for any catalytic RNA to date. Comparison of the structures of its constituent domains free and fully assembled demonstrates that the ...
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AbstractThe hairpin ribozyme is a naturally occurring RNA that catalyzes sequence‐specific cleavage and ligation of RNA. It has been the subject of extensive biochemical and structural studies, perhaps the most detailed for any catalytic RNA to date. Comparison of the structures of its constituent domains free and fully assembled demonstrates that the ...
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Ribozyme Structures and Mechanisms
Annual Review of Biophysics and Biomolecular Structure, 2000▪ Abstract The past few years have seen exciting advances in understanding the structure and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed insight into the folds of RNA molecules. Models of other biologically important RNAs have been constructed based on structural, phylogenetic, and biochemical data ...
Elizabeth A. Doherty, Jennifer A. Doudna
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Journal of Physical Chemistry B, 2015
X-ray crystallography can provide important insights into the structure of RNA enzymes (ribozymes). However, the details of a ribozyme's active site architecture are often altered by the inactivating chemical modifications necessary to inhibit self ...
V. Mlýnský +7 more
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X-ray crystallography can provide important insights into the structure of RNA enzymes (ribozymes). However, the details of a ribozyme's active site architecture are often altered by the inactivating chemical modifications necessary to inhibit self ...
V. Mlýnský +7 more
semanticscholar +1 more source
Hovlinc is a recently evolved class of ribozyme found in human lncRNA
Nature Chemical Biology, 2021Yue-Qin Chen +6 more
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Practical Ribozymes: Making ribozymes work in cells
Current Biology, 1994Ways are being found to increase the efficacy of ribozymes in cells, offering hope that they may soon begin to fulfill their promise as new reagents for inactivating specific RNAs in cells.
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Thermodynamic Dissection of the Substrate−Ribozyme Interaction in the Hammerhead Ribozyme
Biochemistry, 1998The free energy of substrate binding to the hammerhead ribozyme was compared for 10 different hammerheads that differed in the length and sequence of their substrate recognition helices. These hammerheads were selected because neither ribozyme nor substrate oligonucleotide formed detectable alternate secondary structures.
Tracy K. Stage-Zimmermann +3 more
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