Results 61 to 70 of about 203 (148)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Ricâl Tenkidinin Rivayet Pratiklerine Etkisi: Süleyman b. Erkam Özelinde Bir İnceleme

Marife Dini Araştırmalar Dergisi
Bu çalışma, muhaddislerin, zayıf râvilerden uzak durulması yönündeki eğitsel müdahalelerinin etkinliğini bir râvi üzerinden değerlendirmektedir. Araştırma kapsamında örnek olarak seçilen râvi, dönemin muhaddisleri tarafından "Biz gençken hocalarımız ...
Mustafa Oral
doaj   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Urban Regeneration and Affective Connections to Place in Bucharest City Centre [PDF]

Annals of the University of Bucharest: Geography Series, 2013
“Place” represents an important issue for human geo graphers. This paper deals with the process of urban change that has affected the histo rical centre of Bucharest over the course of the last decade.
LILIANA DUMITRACHE, MARIANA NAE
doaj  

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Study of Photoluminescence Behaviour of Porous Silicon Samples Prepared at 20 mA Current Density

Журнал нано- та електронної фізики, 2013
The paper presents a study on a series of porous silicon films of various thicknesses, prepared at 20 mA current density using a photoluminescence fitting model to determine the average crystallite size of sphe-rical shaped interconnected silicon quantum
R. Kumar, Neeraj Dhiman, Kiran Sharma, Pankaj K. Pal, L.P. Purohit, Himanshu Gupta, Fateh Singh Gill, R.M. Mehra   +7 more
doaj  

Hicri 3. asrın başlarında sünnete sarılmak: “saç-sakalını da boyardı!”

Ankara Üniversitesi İlahiyat Fakültesi Dergisi, 2018
Ravilerin hadis ilmi açısından ehliyetlerini tespit etmeyi hedefleyen biyografik eserlerde, birtakım ravilerin saç-sakallarını boyayıp boyamadıklarına dair kayıtlara tesadüf edilir.
Muhammed Enes Topgül
doaj   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Çok Zayıf Hadis: Bir Mefhumun Geçmişten Günümüze Gelişim Seyri

Kocatepe İslami İlimler Dergisi
Hadis metodolojisinde sahih, hasen ve zayıf diye yapılan temel sınıflandırmalarda, zayıf olarak nitelenen hadislerin kapsadığı alan geniş bir çeşitliliği barındırmaktadır.
Halil İbrahim Turhan, Kadir Zeki
doaj   +1 more source