Results 61 to 70 of about 2,522 (259)
Advanced Science, EarlyView.We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma +22 more
wiley +1 more source
Türkiye Din Eğitimi Araştırmaları Dergisi, 2017 Hadis ve rical bilgisinin yanında telif ettiği rivayet tefsiri ile de Ayyâşî Şia için önemli bir âlim olmuştur. Kendisinden sonraki âlimler onun hadis ve rical bilgisinden çokça faydalanmışlardır.
Recep Emin Gül
doaj
Oorreding in 1 Korintiërs 3:9c-23
In die Skriflig, 2009 Persuasion in 1 Corinthians 3:9c-23 This article is an attempt to analyse 1 Corinthians 3:9c-23 from a perpective different to approaches which tend to force ancient rhetorical categories on the letter. The analysis is done in terms of what is called
A. H. Snyman
doaj +1 more source
Türkiyat Mecmuası / Journal of Turkology, 2020 Kitlik; kuraklik ve dengesiz yagislarin toplumun uretim olanaklarini ortadan kaldirmasiyla ortaya cikan dogal bir afettir. Bu afet, her ne kadar cografi kosullarin bir neticesi olsa da afetin giderilmesi, devlet mekanizmasinin saglikli isleyisiyle yakindan iliskilidir. Bu mekanizmanin en onemli ayagini basarili ve deneyimli yoneticiler olusturmaktadir.
openaire +3 more sources
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing
Advanced Science, EarlyView.A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo +11 more
wiley +1 more source
Ricâl Tenkidinin Rivayet Pratiklerine Etkisi: Süleyman b. Erkam Özelinde Bir İnceleme
Marife Dini Araştırmalar DergisiBu çalışma, muhaddislerin, zayıf râvilerden uzak durulması yönündeki eğitsel müdahalelerinin etkinliğini bir râvi üzerinden değerlendirmektedir. Araştırma kapsamında örnek olarak seçilen râvi, dönemin muhaddisleri tarafından "Biz gençken hocalarımız ...
Mustafa Oral
doaj +1 more source
Advanced Science, EarlyView.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
Rical tenkidinin doğuşu ve gelişmesi
, 2020 The Hadith which is the second source of İslam after the Holy Qur'an has reached from beginning to nowadays by means of the Rawi (narrators). Almost in every area, especi-ally the authenticity of Hadith, the reliabilty of Rawii has a special importance. For this purpose, from the first century, Islamic scholars examined the Rawiis and if necessary
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