Results 81 to 90 of about 368,937 (267)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

A mediator of OsbZIP46 deactivation and degradation negatively regulates seed dormancy in rice

Nature Communications
Preharvest sprouting (PHS) is a deleterious phenotype that occurs frequently in rice-growing regions where the temperature and precipitation are high. It negatively affects yield, quality, and downstream grain processing. Seed dormancy is a trait related
Naihui Guo, Shengjia Tang, Yakun Wang, Wei Chen, Ruihu An, Zongliang Ren, Shikai Hu, Shaoqing Tang, Xiangjin Wei, Gaoneng Shao, Guiai Jiao, Lihong Xie, Ling Wang, Ying Chen, Fengli Zhao, Zhonghua Sheng, Peisong Hu   +16 more
doaj   +1 more source

CRISPR-mediated promoter editing of a cis-regulatory element of OsNAS2 increases Zn uptake/translocation and plant yield in rice

Frontiers in Genome Editing
Developing nutritious rice with a higher yield is one approach to alleviating the problem of micronutrient deficiency in developing countries, especially human malnutrition involving zinc and iron (Fe) deficiency, and achieving better adoption.
Yvonne Ludwig, Conrado Dueñas, Erwin Arcillas, Reena Jesusa Macalalad-Cabral, Ajay Kohli, Russell Reinke, Inez H. Slamet-Loedin   +6 more
doaj   +1 more source

Correcting Apparent Priming Bias Unveils Fertilizer Nitrogen‐Risk Archetypes of Surplus and Depletion Across Asian Rice Systems

Advanced Science, EarlyView.
Correcting the apparent priming effect resolves systematic biases in Asian rice fertilizer nitrogen accounting. Net soil retention drops below 7%, while 48% of fertilizer escapes, inflicting US$98.53 billion in annual reactive‐nitrogen damages. High‐resolution mapping uncovers N‐risk archetypes across 42% of the rice area, delivering a spatially ...
Xiuyun Liu, Siyuan Cai, Longlong Xia, Jagdish K. Ladha, Xiaoyuan Yan, Xu Zhao   +5 more
wiley   +1 more source

Engineering unnatural cells with a 21st amino acid as a living epigenetic sensor

Nature Communications
Living animals rely extensively on post-translational modifications (PTMs) to regulate protein activity, stability, subcellular localization, and protein-protein interactions.
Yu Hu, Yixian Wang, Linqi Cheng, Chenhang Wang, Yijie Liu, Yufei Wang, Yuda Chen, Shudan Yang, Yiming Guo, Shiyu Jiang, Kaiqiang Yang, Han Xiao   +11 more
doaj   +1 more source

Correction to: Validation of a QTL for Grain Size and Weight Using an Introgression Line from a Cross between Oryza sativa and Oryza minuta

Rice, 2021
Yue Feng, Xiaoping Yuan, Yiping Wang, Yaolong Yang, Mengchen Zhang, Hanyong Yu, Qun Xu, Shan Wang, Xiaojun Niu, Xinghua Wei   +9 more
doaj   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Biomimetic Self‐Reconfigurable Soft Gripper for Cross‐Scale, Multi‐Particle, and High‐Load Multifunctional Manipulation

Advanced Science, EarlyView.
A fully soft, self‐reconfigurable gripper inspired by rapeseed flowers is monolithically 3D‐printed and electronics‐free, switching between diagonal and parallel finger arrangements. Establishing a self‐reconfigurable grasping paradigm, the gripper enables diverse manipulation tasks, including rotating bulbs, picking fruits, grasping cross‐scale ...
Qiping Xu, Bin Wang, Jinxin Chen, Zhengqiang Guo, Baisong Yang, Chaoqian Chen, Jiancheng Cai, Chee‐Meng Chew, Shiju E   +8 more
wiley   +1 more source