Results 31 to 40 of about 561,147 (283)
Contribution of MUTYH variants to male breast cancer risk: results from a multicenter study in Italy [PDF]
, 2018 Inherited mutations in BRCA1, and, mainly, BRCA2 genes are associated with increased risk of male breast cancer (MBC). Mutations in PALB2 and CHEK2 genes may also increase MBC risk.
Azzollini, Jacopo +25 more
core +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Rivista Italiana di Informatica e Diritto, 2023 La ricerca è essenziale per il progresso scientifico, culturale e sociale e sarà fondamentale per la ripresa economica e sociale nel mondo post-pandemico.
Christophe Geiger, Bernd Justin Jütte
doaj +1 more source
Ricerca preliminare sui fabbisogni formativi per la definizione della figura professionale del Manager dello sviluppo locale [PDF]
, 2002 Indice della ricerca: Introduzione. L'esperienza del Master in International Development: l'azione locale nella prospettiva internazionale. L'evoluzione dell'esperienza. Il Master Operatori allo Sviluppo Gli obiettivi della ricerca.
Frascani, Paolo +4 more
core
Effectiveness is the gold standard of clinical research [PDF]
, 2017 Psychological treatments have been shown to be at least as effective (and sometime even more effective) than psychotropic medications for many psychiatric disorders, in particular anxiety disorders, depressive disorders, and personality disorders ...
Formica, Ivan +4 more
core +3 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Fast Spherical Harmonic Analysis: a quick algorithm for generating and/or inverting full sky, high resolution CMB Anisotropy maps [PDF]
, 1997 We present a fast algorithm for generating full sky, high resolution ($\sim 5'$) simulations of the CMB anisotropy pattern. We also discuss the inverse problem, that of evaluating from such a map the full set of $a_{\ell m}$'s and the spectral ...
Bartoloni A. +4 more
core +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Nonparaxial dark solitons in optical Kerr media [PDF]
, 2005 We show that the nonlinear equation that describes nonparaxial Kerr propagation, together with the already reported bright-soliton solutions, admits of (1 + 1)D dark-soliton solutions. Unlike their paraxial counterparts, dark solitons can be excited only
Ciattoni, Alessandro +3 more
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source