Results 61 to 70 of about 2,626,076 (297)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Sedimentation and subsidence history of the Lomonosov Ridge [PDF]

, 2006
During the first scientific ocean drilling expedition to the Arctic Ocean (Arctic Coring Expedition [ACEX]; Integrated Ocean Drilling Program Expedition 302), four sites were drilled and cored atop the central part of the Lomonosov Ridge in the Arctic ...
Kaminski, M., Backman, J., Martinez, N.C., Pälike, H., Smith, D.C., Jakobsson, M., Rio, D., Matthiessen, J., Rea, B., O'Regan, M., Moore, T.C., King, J., Onodera, J., Brinkhuis, H.K., Takahashi, K., Sakamoto, T., Watanabe, M., T.C. Moore, Koç, N., Rea, B.R., Dickens, G.R., Clemens, S., Stein, R., Brinkhuis, H., Suto, I., Eynaud, F., Gattacceca, J., Cronin, T., St. John, K.E.K., Moran, K., Moore Jr., T.C., Yamamoto, M., Jordan, R.W., McInroy, D., Suzuki, N.   +34 more
core   +1 more source

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

“It gets your foot in the door”: An examination of the Healthy Apples Self-Care Program at Durham Regional Police Service

Social Sciences and Humanities Open
The psychological strain inherent to the policing profession and the effect of psychological strain on sworn and civilian members are increasingly recognized.
Rosemary Ricciardelli, Mark Jones, Evan Cross, Krystle Martin, Stanley R. MacLellan   +4 more
doaj   +1 more source

The effect of the basic variables on the movement of railway transport and Processed using ridge regression approach. [PDF]

مجلة التربية والعلم, 2009
The movement of travelers represents a good induction to the train transference efficiency with the existence of another indications. So the research aims to recognize, the impact of one of the basic variables was (transference technique) which is ...
Riyad Murtada, Fareed Alsefo
doaj   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Active Long-Lived Faults Emerging Along Slow-Spreading Mid-Ocean Ridges [PDF]

Oceanography, 2012
In the classic mid-ocean ridge model, new seafloor is generated through a combination of magmatic diking feeding lava flows at the spreading axis, and the formation of short-offset, high-angle normal faults that dip toward the axis.
Deborah K. Smith, Javier Escartín, Hans Schouten, Johnson R. Cann   +3 more
doaj  

Calendar Year 2000 Groundwater Monitoring Report for the Groundwater Protection Program, U.S. Department of Energy, Y-12 National Security Complex Oak Ridge, Tennessee [PDF]

, 2001
This report contains the groundwater and surface water monitoring data that were obtained at the US Department of Energy (DOE) Y-12 National Security Complex (hereafter referenced as Y-12) in Oak Ridge, Tennessee, during calendar year (CY) 2000. These monitoring data were collected for the specific purposes of DOE Order 5400.1 site surveillance ...
openaire   +2 more sources

Oak Ridge National Laboratory Report ORNL-2518

, 1958
Report issued by the Oak Ridge National Laboratory displaying a single chart showing measurements of the gamma-ray, fast-neutron, and thermal-neutron dose ...
Oak Ridge National Laboratory
core  

Mesoporous‐Shell Monolayer Plasmonic Architecture Enables Quantitative and Decision‐Guided SERS

Advanced Science, EarlyView.
Mesoporous‐shell‐regulated molecular transport combined with monolayer hotspot determinism transforms surface‐enhanced Raman spectroscopy (SERS) from ultrasensitive detection into quantitative and decision‐guided molecular sensing. ABSTRACT Quantitative surface‐enhanced Raman spectroscopy (SERS) has long been impeded by stochastic hotspot formation ...
Guangyao Huang, Ying Wang, Yue Fang, Jingyuan Shao, Sensen Hao, Mancun Zhao, Yuan Yao, Junping Wang, Wei Zhou, Hongzhi Wang   +9 more
wiley   +1 more source