Results 121 to 130 of about 72,471 (294)

De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He   +7 more
wiley   +1 more source

Fast parallel quantification of dual drug systems via UV-VIS spectrometry – a case study with antibiotic substances

open access: yesCurrent Directions in Biomedical Engineering, 2017
Implant-based drug delivery necessitates a rigorous quantitative assessment and quality control of the drug release behavior. In this context, a fast simultaneous UV-VIS spectrometer quantification method was developed for an antibiotic dual drug system.
Eickner Thomas   +5 more
doaj   +1 more source

Assessment of the Effects of Fruquintinib on Cardiac Safety in Patients with Metastatic Colorectal Cancer

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 11, Page 1411-1419, November 2025.
Abstract Fruquintinib is a highly selective oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, approved by the US Food and Drug Administration and the European Commission for the treatment of previously treated metastatic colorectal cancer (mCRC), regardless of biomarker status. This study used concentration QT interval (C‐QTc)
Xiaofei Zhou   +7 more
wiley   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 11, Page 1420-1432, November 2025.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora   +4 more
wiley   +1 more source

Prevalence of Post‐Operative Infections Related to Third Molar Surgery at an Australian University Teaching Clinic: A 5‐Year Retrospective Study

open access: yesOral Surgery, Volume 18, Issue 4, Page 451-461, November 2025.
ABSTRACT Aim To assess the prevalence of post‐operative infection related to surgical third molar extractions at a university teaching hospital. The secondary outcome was to investigate risk factors relating to post‐operative infections, including the use of prophylactic antibiotics.
Joshal Mehta, Riddhika Ram, Peter Reher
wiley   +1 more source

Mutations in 1700 Bp Fragment of Rpob Gene of Multi-drug Resistant Mycobacterium Tuberculosis Isolate [PDF]

open access: yes, 2012
This research aimed to amplify a 1700 bp fragment of rpoB gene of multidrug resistance M. tuberculosis (MDR-TB) isolate and determine types of mutation beyond the core region (hot-spot region).
Junitha, I. K. (I)   +3 more
core  

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