Results 131 to 140 of about 86,105 (313)
Is Mycobacterial InhA a Suitable Target for Rational Drug Design?
ChemMedChem, Volume 20, Issue 13, July 1, 2025.InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet +7 more
wiley +1 more source
Journal of Biological Researches, 2012 Rifampin is a key component in the chemoterapeutic regimens used to combat both leprosy and tuberculosis. Owing to exquisite rifampin susceptibility of Mycobacterium leprae, this drug is the backbone of the multidrug therapy currently recommended by WHO
E Bimo Aksono H
doaj +1 more source
Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report [PDF]
, 2018 Rationale: Tuberculous meningitis is a highly morbid, often fatal disease. Patient concern: We describe a case of an Italian child. Diagnoses: we diagnosed early a Tuberculous meningitis complicated by the occurrence of hydrocephalus, stroke, and ...
Ajassa, Camilla +8 more
core +1 more source
Antimicrobial Agents and Chemotherapy, 2017 Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (
D. Sloan +11 more
semanticscholar +1 more source
New Microbes and New Infections, 2021 Multidrug-resistant (MDR) Mycobacterium tuberculosis strains, defined as resistant to at least isoniazid and rifampin, have emerged as a major worldwide health threat. Spontaneous point mutations in various genes of M.
B. Motavaf +5 more
doaj
Biomédica: revista del Instituto Nacional de Salud, 2017 Introducción. La tuberculosis es un problema de salud pública a nivel mundial. En 2014, la Organización Mundial de la Salud estimó que se habían presentado 9,6 millones de casos nuevos y 480.000 multirresistentes.
Claudia Llerena +3 more
doaj +1 more source
Effect of Prednisolone and Rifampin on Isoniazid Metabolism in Slow and Rapid Inactivators of Isoniazid [PDF]
, 1980 The effect of prednisolone and rifampin, alone and in combination, on the biodisposition of isoniazid in slow and rapid inactivators of isoniazid was investigated.
Kailasam, S +4 more
core +2 more sources
PLoS ONE, 2016 Few effective therapeutic options are available for treating severe infections caused by extensively drug-resistant Acinetobacter baumannii (XDR-AB). Using a murine thigh-infection model, we examined the in vivo efficacy of colistin in combination with ...
Bing Fan, J. Guan, Xiumei Wang, Y. Cong
semanticscholar +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 146-155, July 2025.A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang +6 more
wiley +1 more source
High sporulation and overexpression of virulence factors in biofilms and reduced susceptibility to vancomycin and linezolid in recurrent Clostridium [Clostridioides] difficile infection isolates [PDF]
, 2019 Clostridium [Clostridioides] difficile infection (CDI) is one of the leading causes of diarrhea associated with medical care worldwide, and up to 60% of patients with CDI can develop a recurrent infection (R-CDI). A multi-species microbiota biofilm model
Baines, Simon +9 more
core +1 more source