Results 121 to 130 of about 16,739,290 (349)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Book review: the influence of think tanks: presenting the right ideas, to the right people, at the right time [PDF]
, 2012 The In Think Tank: The Story of the Adam Smith Institute, Madsen Pirie documents the fascinating history of one of the world’s biggest think tanks, and the many projects in which it has been engaged over the past three decades.
Abelson, Donald
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Rethinking of Fair Trial in the Light of Balance Principle of Rights of Victim and Accused [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2015 According to the conventional definition, fair trial is a trial by acompetent tribunal in accordance with procedural guarantees to protect thedefendants’ constitutional and legal rights especially in order to respecthis/her human dignity and presumption ...
Mehrdad Rayijian Asli
doaj
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Right-Orientation in Criminalization; With Emphasis on the German Theory of Legal Interests [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2014 Criminalization theory originally supports restriction of criminal law’s border. The question which has been risen is whether the construction of existing theories is about the interests and goals or rights?
Firouz Mahmudi janaki
doaj
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Right Atrial Size and Function in Patients with Pulmonary Hypertension Associated with Disorders of respiratory System or Hypoxemia [PDF]
, 2007 Cioffi G +4 more
core +1 more source