Results 61 to 70 of about 868,255 (306)

What it means right of resistance in Hobbes? An apparent trap

This paper is about the meaning of right of resistance in Thomas Hobbes political theory. It is reasonable to say that right of resistance it might be a trap, put up by Hobbes himself, and taken as the basis of his theory.
Furlan, Lorenzo Emanuelli
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Noninvasive Estimation of Pulmonary Vascular Resistance Using Right Ventricular Outflow Doppler Analysis

JACC: Advances
Background: Right heart catheterization (RHC) is the gold standard for measuring pulmonary vascular resistance (PVR). Current noninvasive methods lack accuracy, especially in moderate to severe pulmonary arterial hypertension.
Luis Afonso, MD, Chandra Kanth Ala, MD, Aditya Sood, MD, Oluwole Adegbala, MD, MPH, Farima Kahe, MD, John Dawdy, MD, Kendall Bell, MD, Abdul Rasheed Bahar, MD, Nimrod Blank, MD   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Right to Resistance. Could it be built in peace?

Revista de Cultura de Paz, 2019
The Right to Resistance (DR) as legal and political fiction, generates scenarios of complex reasoning, as a right or as an anti-right. In Latin America, it has become positive in some of its legal systems, however, its interpretation remains subjective ...
Marcelo Costa Cevallos, Enrique Luzuriaga Muñoz, Santiago Pérez Samaniego   +2 more
doaj  

Refinement of the Co-Content function, through an integration of a polynomial fit of $$I-{I}_{sc}$$ I - I sc . Part 2 application to experimental current–voltage curves

Discover Electronics
In this article Part 2 of this series of articles, the methodology proposed in Part 1, namely, the fitting to a polynomial of the current minus the short-circuit current, i.e., $$I-{I}_{sc}$$ I - I sc , to calculate the Co-Content function $$\left(CC ...
Victor-Tapio Rangel-Kuoppa
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Соціальні конфлікти і соціальна безпека: Українська "multiple personality" в контексті Європейського "right of resistance" і Російських "смуты и бунта"

, 2020
Бобіна, О. В. Соціальні конфлікти і соціальна безпека: Українська "multiple personality" в контексті Європейського "right of resistance" і Російських "смуты и бунта" = Social conflicts and social security: the Ukrainian "multiple personality" in the ...
Bobina, O. V., Шаповалова, І. В., Shapovalova, I. V., Kravchuk, O. Yu., Бобіна, О. В., Кравчук, О. Ю.   +5 more
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