Results 71 to 80 of about 868,255 (306)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Henri Clavier, The duty and the right of Resistance according to the Bible and to the Church, 1956

, 1956
Clavier Henri. Henri Clavier, The duty and the right of Resistance according to the Bible and to the Church, 1956. In: Revue d'histoire et de philosophie religieuses, 36e année n°3,1956.
Clavier, Henri
core  

Two Views on the Right of Resistance. Kant’s Denial of the Right of Resistance, and the Resistance to Tyranny as the Duty of the People in Vindiciae contra tyrannos

U članku se analizira odnos između vladara i naroda u filozofiji prava Immanuela Kanta i monarhomaškom djelu Vindiciae contra tyrannos i razmatra se pitanje: može li se narod suprotstaviti tiraninu i svrgnuti ga?
Mihailović, Andreja, Dokić, Marko, Bakrač, Vladimir   +2 more
core   +1 more source

Atypical presentation of an infant with idiopathic pulmonary arterial hypertension: pericardial tamponade

Türk Kardiyoloji Derneği Arşivi, 2014
In this report, we present a five-month-old female patient with a diagnosis of idiopathic pulmonary arterial hypertension (IPAH). This patient was accepted by our clinic after a sudden deterioration in her clinical condition.
Murat Saygı, Öykü Tosun, Yakup Ergül, Ender Ödemiş   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

John Witherspoon and the right of resistance

, 1989
This study investigated one central aspect of the political views of John Withexspoon: His steadfast belief in the right of resistance. A product of the Reformation and Enlightenment movements, this doctrine offered justification for questioning the ...
Bartley, David D.
core  

The Right of resistance and tyrannicide in calvinism

, 2015
This study aims to analyze the developments and the radicalization of the Protestant Reformation in the context of so-called religious wars, especially in the French environment. The episode known as Night of St.
Morais, Gerson Leite de
core   +1 more source

One Size Does Not Fit All: Precision Combinations for FGFR4-driven Cancers

Frontiers in Bioscience-Landmark
Oncogenic FGFR4 signalling represents an attractive therapeutic target across multiple cancers, yet treatment resistance almost uniformly occurs. A critical mechanism steering resistance is a rapid and complex reprogramming of kinase signalling networks,
Emmy D.G. Fleuren
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source