Results 161 to 170 of about 9,500,361 (289)

Unquestioned testimony: How the diminution of live testimony threatens the accused’s right to be present during international criminal trials

, 2019
It is generally recognized that international criminal law provides the accused with a right to be present at trial. There are two components of that right which make it meaningful: first, as a right it can only be derogated from through an affirmative waiver made by the accused; and second, it requires more than the mere presence of the accused in the
openaire  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Right to be Present as a Guarantee of Justice in Procedure

, 2020
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THE RIGHT TO BE HUMAN AND THE CHALLENGES OF ITS IMPLEMENTATION: FROM HISTORICAL ORIGINS TO THE PRESENT

Рurpose: the article explores the problematic aspects of the right to be human and its implementation from historical origins to the present day. Research methods: to achieve the defined goal, general and special scientific (specialized) methods were used, including dialectical, historical, structural-functional, comparative, logical-legal methods, and
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Malignant mesothelioma of the tunica vaginalis testis: A case report. [PDF]

Oncol Lett
Lu Y, Miu J, Fan Z, Zhi Z, He L, Deng J, Shao X, Hua J, Qian Y, Xie J.   +9 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Practical Challenges and Best Practices Regarding the Right to be Present in Austria

, 2020
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The Meeting – The Apartment – Conversations. The Right to Be Present: An Inclusive Project in Search of Its Own Place in Russia’s Theatrical Art of the 2010s and Early 2020s

The article questions the place of inclusive theatre in the space of Russian culture in the country’s growing autocracy (2010–2020). Through the optics of the spatial turn formulated by Erika Fischer-Lichte and Benjamin Wihstutz, the article explores the work of one of Russia’s most important inclusive collectives of this period, a neurodiverse group ...
openaire   +1 more source

Extensive cerebral venous sinus thrombosis with hemorrhagic venous infarction as the initial presentation of acute myeloid leukemia: A case report. [PDF]

Radiol Case Rep
Bajafar A, Almuzaini NO, Alanazi A, Alharbi HS, Alghanmi AK.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source